The target trial is an increasingly popular conceptual device for guiding the design and analysis of observational studies that seek to perform causal inference. As tends to occur with concepts like this, there is variability in how certain aspects of the approach are understood, which may lead to potentially consequential differences in how the approach is taught, implemented, and interpreted in practice. In this commentary, we provide a perspective on two of these aspects: how the target trial should be specified, and relatedly, how the target trial fits within a formal causal inference framework.
翻译:暂无翻译