This chapter presents the main lines of agent based modeling in the field of medical research. The general diagram consists of a cohort of patients (virtual or real) whose evolution is observed by means of so-called evolution models. Scenarios can then be explored by varying the parameters of the different models. This chapter presents techniques for virtual patient generation and examples of execution models. The advantages and disadvantages of these models are discussed as well as the pitfalls to be avoided. Finally, an application to the medico-economic study of the impact of the penetration rate of generic versions of treatments on the costs associated with HIV treatment is presented.
翻译:本章介绍医学研究领域基于代理模式的模型主线,总图由一组病人(虚拟或实际)组成,这些病人的演变是通过所谓的演进模型观察的,然后可以通过不同模型的不同参数来探讨各种设想,本章介绍虚拟病人生成技术和执行模型的实例,讨论了这些模型的利弊以及需要避免的缺陷,最后介绍了对普通疗法渗透率对艾滋病毒治疗相关费用的影响的医学-经济研究的应用。