Plaque segmentation via masking of the artery wall

The presence of plaques in the coronary arteries are a major risk to the patients' life. In particular, non-calcified plaques pose a great challenge, as they are harder to detect and more likely to rupture than calcified plaques. While current deep learning techniques allow precise segmentation of regular images, the performance in medical images is still low, caused mostly by blurriness and ambiguous voxel intensities of unrelated parts that fall on the same range. In this paper, we propose a novel methodology for segmenting calcified and non-calcified plaques in CCTA-CPR scans of coronary arteries. The input slices are masked so only the voxels within the wall vessel are considered for segmentation. We also provide an exhaustive evaluation by applying different types of masks, in order to validate the potential of vessel masking for plaque segmentation. Our methodology results in a prominent boost in segmentation performance, in both quantitative and qualitative evaluation, achieving accurate plaque shapes even for the challenging non-calcified plaques. We believe our findings can lead the future research for high-performance plaque segmentation.