基于有源内腔的复合镀膜式光纤SPR生物传感技术研究

项目名称： 基于有源内腔的复合镀膜式光纤SPR生物传感技术研究

项目编号： No.61775161

项目类型： 面上项目

立项/批准年度： 2018

项目学科： 无线电电子学、电信技术

项目作者： 刘琨

作者单位： 天津大学

项目金额： 16万元

中文摘要： 本项目主要针对生物医药行业对微量样品进行无标记、实时检测的迫切需求，开展基于有源内腔结构的复合镀膜式光纤SPR生物传感技术研究。在有源内腔光纤SPR传感理论模型的基础上，研究光纤SPR传感灵敏度增强机理，探索镀膜工艺、复合膜层结构以及倾斜光栅参数等对光纤SPR传感灵敏度的影响。完善光纤SPR生物传感器制备工艺，构建有源内腔光纤SPR生物传感系统，开发适用于生物分子检测的解调算法，实现生物分子高精度浓度传感。本项目拟着力探索光纤SPR传感灵敏度增强机理，进一步阐明传感器与生物分子耦合的微观机制，构建并完善光纤SPR生物传感系统，为其早日实现实用化奠定坚实基础。

中文关键词： 表面等离子共振；光纤生物传感器；有源内腔；复合镀膜

英文摘要： Mainly aiming at the urgent requirements of label-free and real-time detection for micro-samples in biology and medicine areas, this project will carry out the research on the multi-layer coating type optical fiber SPR bio-sensing technique based on active intra-cavity structure. Based on the theoretical model of active intra-cavity optical fiber SPR sensor, the sensitivity enhancement mechanism for the optical fiber SPR sensing will be explored. And the influences of coating technology, multi-layer film structure and TFBG parameters on the sensitivity of the optical fiber SPR sensing will be discussed. The preparation technology of the optical fiber SPR immuno-sensor will be improved. Then an active intra-cavity structure based optical fiber SPR biological sensing system will be established. The demodulation algorithm for the biomolecule detection is studied, and the sensing experiments of biomolecule can be realized by using this system with a relatively higher sensitivity. This project will focus on the research of the sensitivity enhancement mechanism for the optical fiber SPR sensing. And the interaction mechanism between the optical fiber SPR sensor and the biomolecule will be also clarified further. Finally, the optical fiber SPR bio-sensing system will be established and optimized. And all these works will lay a strong foundation for the practical applications of this technology.

英文关键词： Surface Plasmon Resonance;Fiber Bio-Sensor;Active Intra-Cavity;Multi-Layer Coating