抑郁症认知偏差的神经环路特征与临床意义

项目名称： 抑郁症认知偏差的神经环路特征与临床意义

项目编号： No.91232714

项目类型： 重大研究计划

立项/批准年度： 2013

项目学科： 神经系统疾病、精神疾病

项目作者： 李凌江

作者单位： 中南大学

项目金额： 70万元

中文摘要： 基于目前国内外抑郁症神经环路研究进展和本课题组相关在研课题的新发现，提出抑郁症的发生有可能是在抑郁情绪发生的基础上，由于心理上的认知偏差和认知相关神经环路异常所致的假说。即认知功能相关的神经环路在抑郁症的发生发展中起着至关重要的决定性作用。采用多模态神经影像学方法、ERP、SPECT及认知心理测评技术，对有无认知偏差的抑郁症患者治疗前后、一级亲属、健康对照者的比较研究，从脑功能、结构、连接等角度，试图澄清抑郁症神经环路尤其是与认知活动相关脑区的特征，确定是否具有内表型特点，明确认知相关的神经环路在抑郁症发生发展中的作用。建立抑郁症的临床病理标记的神经环路的结构和功能的定量描述模型，为下一步研究抑郁症的基因-环境相互作用提供重要的中介靶点。

中文关键词： 抑郁症；认知；神经环路；磁共振；情绪

英文摘要： Based on the current research progress of neural circuit in major depressive disorder and new findings of our relevant studies, we put forward a hypothesis that depression was induced by psychological cognition bias and abnormal of cognition-related neural circuit on the basis of depressive emotion. Cognitive disfunction related neural circuit plays a vital and decisive role in the pathophysiology of depression. We plan to use multimodal neuroimaging, ERP, SPECT and cognitive psychological measurements to make a comparison among depression patients with and without cognition bias before and after treatment, first-degree relatives and healthy controls, try to 1)clarify the characteristics of neural circuit, especially brain regions of cognitive activity in depression, 2)reveal whether it is an endophenotype of depression, 3)make sure the function of cognition-related neural circuit in the pathophysiology of depression, 4)establish the quantitative description model of structure and function of neural circuit with clinical pathological markers of depression and 5)provide an important intermediary target to study the interaction of gene and environment in depression from the aspects of brain function, structure and connection.

英文关键词： major depressive disorder；cognition；neural circuit；Magnetic Resonance Imaging；emotion