活体脑基底节多组分神经化学微阵列传感器研究

项目名称： 活体脑基底节多组分神经化学微阵列传感器研究

项目编号： No.61501426

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 无线电电子学、电信技术

项目作者： 宋轶琳

作者单位： 中国科学院电子学研究所

项目金额： 23万元

中文摘要： 脑基底节是位于大脑深部的一组神经核团，其内部多种神经化学物质的动态调控与许多神经精神性疾病密切相关，而现有技术无法实现这些神经化学物质的活体原位多组分实时同步检测。本项目面向脑神经疾病研究对新型传感器及检测技术的迫切需求，基于微纳加工技术、电极表面修饰技术、电化学传感器技术，开展活体脑基底节多组分神经化学微阵列传感器研究。重点围绕多层生物活性功能材料高选择性定向修饰、多组分神经化学信号高时间分辨率同步检测的关键科学问题，进行微电极阵列设计制备、表面修饰、电化学测试及动物活体验证研究。拟研制一种新型多通道、高时空分辨率、高选择性、高灵敏度的植入式微阵列传感器，实现对活体大鼠脑基底节多种神经化学物质的实时同步检测，建立传感器研制测试新理论新方法，取得原创性成果。该传感器不仅为揭示脑基底节神经化学调节机制提供有效工具，同时在神经科学研究前沿领域具有广泛的科学意义和潜在的应用价值。

中文关键词： 微电极阵列；神经递质；活体；脑基底节；神经化学

英文摘要： Basal ganglia are a group of nucleus located in the deep brain, which contains a variety of neurochemicals. The dynamical regulation between these neurochemicals is closely related to many neuropsychiatric disorders, while in vivo and in situ real-time synchronous detection of the multicomponent neurochemicals is hard to achieve based on existing technologies. This project is aimed at the urgent need for a new biosensor and related technologies in the research field of neurological diseases. Based on micro-nanofabrication technologies, electrode-surface modification technology, and electrochemical sensor technology, the researches on microarray sensor for basal ganglia multicomponent neurochemical detection in vivo will be carried out. Focused on the key scientific issues of highly selective directional modification of multilayer bioactive functional materials, and high temporal resolution synchronous detection of multicomponent neurochemical signals, the studies will be conducted on microelectrode array design and fabrication, surface functional modification, multi-channel electrochemical measurements and animal experimental verification in vivo. A multi-channel implantable microarray sensor with high spatial and temporal resolution, high selectivity and high sensitivity will be developed, and real-time synchronous detection of the multicomponent neurochemicals in basal ganglia of living rat will be achieved. New theories and new methods on research and test of the sensor will be established, and original achievements will be obtained. The sensor not only provides an effective tool for revealing the neurochemical regulating mechanisms in the basal ganglia, but also has a wide range of scientific significance and potential applications in the frontier of neuroscience research.

英文关键词： microelectrode array;neurotransmitter;in vivo;basal ganglia;neurochemical