项目名称: 葛根素对性未成熟小白鼠发育不同阶段激素含量和乳腺组织中受体基因表达及泌乳作用的影响研究
项目编号: No.30860208
项目类型: 地区科学基金项目
立项/批准年度: 2009
项目学科: 武器工业
项目作者: 巴音吉日嘎拉
作者单位: 内蒙古农业大学
项目金额: 25万元
中文摘要: 葛根素(Puerarin )为豆科葛属植物葛根异黄酮的主要有效成分之一,是一种异黄酮成分,结构相似刺激素,普遍认为有刺激素杨作用。但至今还未见葛根素对乳腺发育方面的研究,因此为了葛根素的开发利用提供新的实验依据,尤其产科疾病的治疗与增乳添加剂方面开辟新的方法与新的途径,本文葛根素对奶山羊的泌乳和葛根素对小白鼠从青春期开始到性成熟期不同发育阶段血清激素含量和受体基因表达量变化的研究。结果显示,葛根素对奶山羊的产奶量具有一定程度的增乳作用,葛根素对青春期小白鼠血清激素含量和乳腺组织中受体基因表达的不同时期的调控作用,与其雌激素样作用有关。
中文关键词: 葛根素;雌二醇;孕酮;受体
英文摘要: The main active component of the Puerarin is kudzu root isoflavone. Leguminous plant.Pueraria Lobata Ohwi. Which is the ingredient of the isoflavone.structually similar to the stimulin. Generally considered to having the function of stimulin. But there are still no researches on mammary gland development and therefore provide a new experimental basis for the development and utilization of Puerarin. Especially opening up the new methods and new ways to the treatment of reproduction diseases and increase milk additive. This article expresses the affect of the Puerarin on dairy goat lactation from onset of puberty to sexual maturity at different stages in development about how serum hormone concentration receptor gene expression changes. The results illustrates that Puerarin contributes to increase milk yield for dairy goat on a certain extent. and its regulation of receptor gene expression on the breast issue and serum Hormones contents of the mice in different period. as puberty. with the relevant of estrogen-like effects.
英文关键词: progesterone;estrogen receptor;progesterone receptor