1,2,3,4,6-pentagalloyl-β-D-葡萄糖对模拟自然暴露的稀土的驱排作用研究

项目名称： 1,2,3,4,6-pentagalloyl-β-D-葡萄糖对模拟自然暴露的稀土的驱排作用研究

项目编号： No.21201124

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 无机化学

项目作者： 赵文华

作者单位： 首都医科大学

项目金额： 25万元

中文摘要： 由于稀土的广泛农用和饲用，通过环境和经由食物链等渠道进入人体内的稀土正在对人体健康产生令人担忧的负面影响。以植物性食谱和动物性食谱累加计算，人日摄入稀土量远远超出允许量。分子水平和细胞水平研究表明，稀土口服可经消化道吸收，长期低剂量摄入可引起神经毒性、肝毒性和骨质疏松。稀土在体内代谢速度很慢，连续摄入的稀土很难完全代谢。采用络合治疗，是消除稀土中毒的最好选择。1,2,3,4,6-pentagalloyl-β-D-葡萄糖（PGG）是低毒性天然产物。申请人的前期研究证实，PGG可以原型入血。PGG具有独特的多元酚结构，能在生理条件下与稀土离子螯合，从而降低稀土离子的毒性。本项目拟在稀土染毒的鼠模型上，考察PGG对蓄积在器官、骨骼和血液中稀土的驱排作用、考察PGG在驱排稀土时，干扰微量元素的副作用。本项目的目标是，揭示PGG作为稀土中毒解毒剂的临床前景。

中文关键词： 稀土；1;2;3;4;6-pentagalloyl-β-D-葡萄糖；驱排；；

英文摘要： Rare earth elements (REEs), denoting 15 lanthanide elements of group III A (yttrium and scandium included) in periodic table, share very similar physical and chemical properties.Over the past 30 years, applications of REEs have been rapidly expanded in industry, agriculture, forestry and animal husbandry. REE-based microfertilizers have been widely applied to enhance yield and improve quality of crops and vegetables owing to their specific properties. As a result, more and more REEs from anthropogenic sources enter the environment, which may lead to accumulate in the body and trigger adverse effects on health. Continuous exposure of small quantity of REEs which can not be completely eliminated out can cause neurotoxicity, hepatotoxicity, and osteoporosis . 1, 2, 3, 4, 6-pentagalloyl-β-D-glucose （PGG）is a polyphenolic compound highly enriched in a number of medicinal herbals and can enriched in the blood consequently chelated with REEs in the body condition. The aim of this study was to examine the REEs decorporation effect of 1, 2, 3, 4, 6-pentagalloyl-β-D-glucose in vitro and in vivo.

英文关键词： Rare earth elements；1; 2; 3; 4; 6-pentagalloyl-β-D-glucose；decorporation；；