点击反应制备基于介孔氧化硅的二维分子印迹材料

项目名称： 点击反应制备基于介孔氧化硅的二维分子印迹材料

项目编号： No.21472038

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 许志锋

作者单位： 衡阳师范学院

项目金额： 82万元

中文摘要： 本项目旨在建立一个全新的二维（2D）分子印迹方法。以甾族类化合物或喹诺酮类药物为模板分子，以叠氮基修饰的β-环糊精为主要功能单体，通过模板分子对功能单体的组装作用确定功能单体的相对位置，继而通过点击反应将功能单体锚接在介孔氧化硅纳米孔道内壁，得到2D分子印迹材料。 将分子识别中心构建在介孔氧化硅的纳米孔道内，消除传统三维（3D）印迹中生成的高度交联聚合物对识别中心的封闭作用，将识别中心由封闭转为开放，从而有效地提高印迹材料识别中心的可接近性、提高吸附容量和传质速度。 利用点击反应锚接功能单体，使功能单体具有一定的活动性，改变传统3D印迹中利用交联聚合反应冻结功能单体的方法，从而将印迹材料中识别中心的刚性空间变为柔性空间，有望获得分子识别时的诱导契合效果。 本项目的实施将开创分子印迹技术新的研究领域，促进分子印迹技术的发展，也为提高介孔氧化硅材料对客体的选择性的修饰改性提供新思路。

中文关键词： 点击反应；分子印迹；β-环糊精；介孔氧化硅

英文摘要： This program is targeted at establishing an entirely new two-dimensional (2D) molecularly imprinting approach. 2D molecularly imprinted materials for steroids or quinolones will be designed and prepared using azide modified β-cyclodextrin as the main functional monomer and alkynyl-modified mesoporous silicas as the skeleton. The functional monomer molecules are first assembled around the template molecules by formation of template-monomer complexes, and thus, the mutual positions of the functional monomers are fixed. Then, the functional monomers are anchored to the inner walls of the nano-pores of mesoporous silicas via click chemistry. Fabrication of molecular recognition sites in the nano-pores of mesoporous silicas can eliminate the sealed effect caused by the high cross-linked polymers arisen from traditional three-dimensional (3D) imprinting and change the recognition sites from closed to open, which will be beneficial to improving the accessibility of the recognition sites, enhancing the adsorption capacity and facilitating the mass transfer of the imprinted materials. In traditional 3-D imprinting, functional monomers are frozen by cross-linking polymerization. However, in the 2D imprinting strategy, functional monomers are conjugated to the mesoporous silicas skeleton through the exploitation of click chemistry. This method can ensure that the functional monomers are moveable and the recognition centers are flexible, which makes it possible to obtain the induced-fit effect in molecular recognition process of the imprinted materials. If the program has been fulfilled, new research fields of molecular imprinting will be initiated. This will promote the development of molecular imprinting technique. In addition, the program can provide new ideas for modifications of mesoporous silicas with the purpose of enhancing the selectivity.

英文关键词： click reaction;molecular imprinting;β-cyclodextrin;mesoporous silicas