稀土上转换粒子/聚偶氮苯复合中空纳米粒子的合成、NIR光触发载药释放与荧光成像

项目名称： 稀土上转换粒子/聚偶氮苯复合中空纳米粒子的合成、NIR光触发载药释放与荧光成像

项目编号： No.51303049

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 王小涛

作者单位： 湖北工业大学

项目金额： 26万元

中文摘要： 诊断和治疗如何同步是攻克癌症的难点，这要求材料既具备药物可控释放的特点，同时能呈现病灶部位的图像。偶氮苯微球具备远程操控药物释放的优势，但仅能通过短波长的紫外光激发，不仅渗透性差而且可能伤害生物体。本项目设计合成基于稀土上转换材料的聚偶氮苯多功能复合中空微球，一方面，利用稀土粒子在长波长的近红外光激发下，发出紫外光使偶氮苯发挥"光开关"的作用，实现对药物分子的控制释放；另一方面，稀土上装换材料在可见光区域的吸收用于荧光成像。首先，合成包覆SiO2的稀土上转换纳米材料，再在致孔剂存在下，丙烯酸酯类偶氮苯为单体，通过蒸馏沉淀聚合，继而用氟化铵刻蚀SiO2，制得稀土粒子/聚偶氮苯多孔中空材料；另外，选用主链型偶氮苯，丙烯酸为单体，同样的方法制得外壳为偶氮苯交联网络的双响应复合中空微球。深入研究两种复合中空材料在肿瘤细胞中的光控药物释放及荧光成像性，为开发多功能复合纳米粒子提供新的思路和技术基础。

中文关键词： 上转换；稀土上转换发光材料；NaYF4；偶氮苯；诊疗剂

英文摘要： Separation of "diagnostics"and "Theranostics"is a problem in cancer cure.Materials both with controlled release and bioimaging properties were required and called as theranostics.Polyazobenzene microspheres due to their excellent photoisomerization possess predominance of long-distance manipulation. However,UV-light exitation restricted their application in biomedical area. This project designed multi-functional composites based on upconverting materials and azobenzene moieties.One the one hand, upconverting nanomaterials emitted UV-light to isomerize azobenzene under NIR light as photoswitch for controlled release；On the other hand, the emition of visible light was rightly used in bioimaging. Firstly, Silica coated upconverting materials as templates, toluene as porogen,we prepared composites with photoresponsive porous channels in shell. And then chemical method was used to delete SiO2 intermediate layer.Composites with upconverting nanoparticle as core and azobenzene photoswitch as shell were able to prepare.In addition, main chain azobenzene as crosslinker and acrylic acid as monomer, we synthesized pH and light dual responsive composites and could be applied in multi-controlled release and bioimaging.Theoretical principle and technical support were constructed by intensive study on NIR controlled release an

英文关键词： upconversion；upconversion luminescent materials；NaYF4；azobenzene；photo-isomerization