碳量子点纳米复合材料在肿瘤多模态成像和光疗中的应用研究

项目名称： 碳量子点纳米复合材料在肿瘤多模态成像和光疗中的应用研究

项目编号： No.51472252

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 葛介超

作者单位： 中国科学院理化技术研究所

项目金额： 85万元

中文摘要： 光疗技术由于其选择性好,副作用低和创伤小等优点被认为是一种继手术、化疗、放疗后最有前途的肿瘤治疗新技术。多模态成像与光疗技术相结合将实现对癌症的早期诊断和提高治疗效率，而集多模态成像功能与光疗性能于一体的光诊疗试剂是其中的关键。本项目拟以毒性小、生物相容性好、具有优越光疗性能的红光碳量子点为基础， 结合新型钆基富勒烯（Gd3N@C80,Gd@C82）在磁共振成像（MRI）上的优良特性，构建碳量子点/钆基富勒烯纳米复合物，用于肿瘤的多模态成像（荧光/MRI）和光疗。通过调控复合物的尺寸、结构及表面特性，了解这些性质与光疗效果间的关系，发现其新规律；考察不同纳米复合物和肿瘤的相互作用机制；并通过对它们的灵敏性、特异性、体内代谢等特性的评价，以及进一步性能优化，实现对荷瘤鼠体内肿瘤的高效多模态成像和光疗。为深入研究肿瘤发生、发展和转移规律提依据，为开发高效低毒、可代谢纳米光诊疗试剂奠定基础。

中文关键词： 碳量子点；纳米复合物；多模态成像；光疗；肿瘤

英文摘要： Phototherapy has recently been receiving much attention because of its remote controllability, improved selectivity, and low systemic toxicity and been condidering as the most promising new technologies in tumor treatment. Combining multimodal imaging and phototherapy technology together can effectively realize the early diagnosis of cancer and improve the treatment efficiency. Whereas, photo-based nanotheranostic agents, which integrate imaging and therapeutic functions into a single nanoplatform, play key roles in the early diagnosis and therapy of cancer. Recently, our group have developed the multifounctional CQDs that can produce heating and 1O2 efficiently under the light irradiation, which is a key issue for enabling CQDs to act as novel nanotheranostic agents for simultaneous imaging and highly efficient in vivo phototherapy of cancer. This project aims to develop new nanotheranostic agents for simutaneous multimodal FL/MRI imaging and phototherapy of caner based on as-obtained CQDs and gadofullerenes. The research content includes: the preparation of CQDs/gadofullerenes and the subsequent evaluation of biocompatibility, stability, tumor cell specificity and sensitivity, biological safety and the efficacy of phototherapy in vivo.The achievement obtained herein will not only provide fundamental evidence for the occurrence, development and metastasis of tumor, but also establish a foundation for the development of new generation nanotheranostics of tumor.

英文关键词： Carbon Quantum Dots;Nanocompsites;Multimodal Imaging;Phototherapy;Cancer Treatment