多层金纳米壳复合材料的可控制备及其生物医学性能研究

项目名称： 多层金纳米壳复合材料的可控制备及其生物医学性能研究

项目编号： No.51472085

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 李永生

作者单位： 华东理工大学

项目金额： 80万元

中文摘要： 围绕多层金纳米壳复合结构，针对其理论计算具有优异的光热特性但制备困难的问题，本课题创新地设计了以有机硅烷自缩聚形成的有机硅作为中间层的金@有机硅@金纳米复合结构，提出将拉曼报告分子嵌入内核金纳米粒子表面的设计思想，发展一种全新、简单可控的合成策略，得到一类具有优异SERS拉曼成像检测和光热治疗性能的材料。通过研究制备过程中有机硅和金纳米壳层的控制生长、多层金纳米复合结构与其等离子共振和拉曼增强特性之间的关系等基础科学问题，总结出金纳米壳原位还原－生长的机理，解决多层金纳米复合结构制备过程复杂、易团聚、光热稳定性差、拉曼信号弱等关键问题，并为理论研究提供相应的实验基础；同时，这一合成策略还可进一步拓展，将内核更换为不同形状的Ag, Fe3O4等纳米颗粒，制备系列多功能复合结构纳米颗粒。可见，本项目的顺利完成具有重要的学术价值和应用前景。

中文关键词： 纳米复合材料；金纳米壳；SERS；光热；有机硅烷

英文摘要： It has been demonstrated by theoretical study that multilayered gold nanoshells possess excellent photothermal performance due to the unique nanostructure. However, it is very difficult to fabricate with the conventional strategies. In this work, a simple and controllable synthetic route will be developed to obtain monodispersed nanocomposite with a novel Au@organosilica@Au nanostructure. These will be achived by the direct self-condensation of organic silanes to form the organosilica interlayer onto Au core and the subsequent in situ reduction and growth of Au nanoshell.In the meantime, Raman reporting molecules is introduced into the nanostrucutre, so that a novel kind of nanocomposite with SERS and photothermal performance is fabricated. The controlled synthesis of the organosilica and gold nanoshell will be investigated in detail. The growth mechanism of the gold nanoshell will be proposed. With this newly developed methodology, the problems such as the complicated process, the easy aggregation between the nanoparticles and the unstable photothermal and SERS performance of the resultant nanocomposites will be solved. Moreover, this methodology can be employed to synthesize other multifunctional nanocomposite by choosing different structured nanoparticles as the inner cores.

英文关键词： nanocomposite;gold nanoshell;SERS;photothermal;organic silane