人中耳系统结构与功能适应性相互依存的生物力学研究

项目名称： 人中耳系统结构与功能适应性相互依存的生物力学研究

项目编号： No.31500764

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 生物科学

项目作者： 别旭

作者单位： 大连医科大学

项目金额： 19万元

中文摘要： 人中耳包括鼓室、咽鼓管、鼓窦及乳突4部分，我们发现其结构变化是相互影响和依赖的。将三维图像重构、计算生物力学、参数识别反问题理论，与现代耳科基础理论和临床先进医疗检测技术相融合，将人中耳系统作为有机统一的整体进行研究，建立人体中耳系统结构与功能适应性相互依存的生物力学模型；模拟中耳腔某部位结构异常导致中耳腔其他部位结构适应性自塑过程；研究该过程中，中耳腔结构与其物理力学环境发生交互关系时，调整自身几何形态的数学表达式及模型的推导。以人体中耳腔负压导致分泌性中耳炎，从而抑制乳突气房的形态发育这一自适应生物过程为背景，数值模拟中耳腔结构在环境激励下，几何形态发生变化和发展的过程。该模型的建立将对耳科学理论深入研究、中耳腔结构异常导致中耳相关疾病的预测、临床诊断和预防提供数值量化分析的研究平台。试图运用生物力学方法建立人体仿真模型，并量化分析解剖结构变化对功能的影响，以期取得具有创新意义的研究。

中文关键词： 中耳；；生物力学；有限元分析

英文摘要： Human middle ear including 4 parts:the tympanic cavity,the eustachian tube,the antrum and the mastoid process,we find that the changes of these structures depend and influence with each other mutual influence and dependence.We will integrate the three-dimensional image reconstruction, computational biomechanics, parameter identification inverse problem theory and modern otology theory and clinical advanced technology to do the research on the structure and function adaptation of the middle ear;To establish the structure and functional adaptation biomechanical model of human middle ear cavity; To simulate the adaptive self plastic process of middle ear cavity in certain parts of structural abnormalities.Eustachian tube dysfunction can cause secretory otitis media with the negative pressure and fluid in the middle ear cavity, thereby inhibiting the mastoid morphological development; This is the background of our research,then we are going to do the numerical simulation of geometric morphometric changes and development process of middle-ear cavity structure under ambient excitation. The model of scientific theory will provide numerical analysis research platform for the otology theory studying , the prediction of the middle ear disease with abnormal structures, the numerical analysis of clinical diagnosis and prevention. We attempts to seek a kind of biological numerical modeling method in medical research with the inverse problem theory being applied to. The innovative research results is what we are going to achieve.

英文关键词： middle ear;Biomechanics;Finite Element Analysis