神经病理性疼痛的脑结构和功能网络研究

项目名称： 神经病理性疼痛的脑结构和功能网络研究

项目编号： No.81000638

项目类型： 青年科学基金项目

立项/批准年度： 2011

项目学科： 金属学与金属工艺

项目作者： 陈富勇

作者单位： 福建医科大学

项目金额： 10万元

中文摘要： 神经病理性疼痛是一种难治性中枢疾患，对其中枢机制尚未完全清楚。大量研究表明，人脑是一个高效的复杂的"小世界"网络，疾病会导致网络的属性发生改变。但是，在神经病理性疼痛患者中，这种"小世界"网络属性及脑区网络连接是否改变尚不清楚。本课题通过采集脑弥散张量及静息态功能核磁共振数据，基于"小世界"模型和图论的网络分析技术，观察神经病理性疼痛患者与健康志愿者之间、神经病理性疼痛患者术前与行脊髓背根入髓区切开术后的脑结构及功能网络拓扑结构的改变；对于功能网络，进一步基于Granger 因果关系构建有向网络及有效连接，借以深入理解神经病理性疼痛的中枢机制。该研究所建立起来的方法和技术平台，将可以直接应用于其它功能脑病的脑结构和功能网络研究中，对探索帕金森病、精神疾病等功能脑病的发病机制及寻找新的治疗靶点具有重大的理论和临床应用意义。

中文关键词： 神经病理性疼痛;功能核磁共振;弥散张量成像;功能连接;结 构连接

英文摘要： Neuropathic pain is one of the most intractable neurological disorders. However,the cerebral mechanisms involved in pain modulation in patients with chronic neuropathic pain are still not well understood. Most studies have demonstrated that the human networks have the small-world property, and the brain networks are abnormally organized in neurological disorders. To investigate the central mechanisms involved in chronic neuropathic pain, the functional brain networks at rest based on resting-state functional magnetic resonance imaging and the structural brain networks based on diffuse-tensor imaging data were investigated in these patients and comparing it not only with that of matched health controls but also with that of after dorsal root entry zonetomy using graphic theory and small-world property. As to functional brain networks, Granger causality was further used to explore the effective functional connectivity in patients with chronic neuropathic pain. The methods involved in this study can be used to explore the abnormalities of functional and stuctural connectivity and networks of human brain with other neurological and psychiatric diseases, especially Parkinson's diseases, mental disorder, and so on.

英文关键词： neuropathic pain;functional MRI; diffusetensor imaging; functional connectivity; structural connectivity