多功能水溶性上转换复合纳米材料的组装与发光性能研究

项目名称： 多功能水溶性上转换复合纳米材料的组装与发光性能研究

项目编号： No.21301068

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 李春光

作者单位： 吉林大学

项目金额： 25万元

中文摘要： 生物医学成像技术是现代医学和分子生物学上生物活体研究最重要的工具与研究热点，它对于疾病的检测、分析与早期预防十分关键。当前制约该领域发展的主要瓶颈在于生物组织自身荧光的干扰以及荧光标记中探针材料较低的发光强度。基于稀土发光材料自身独特的上转换发光特性，本项目拟选择具有上转换发光的稀土氟化物材料作为研究对象，发展单分散稀土氟化物纳米晶材料的绿色合成方法。围绕在低功率密度激发下水相中稀土上转换发光材料的高荧光强度，本项目还提出开展多功能稀土上转换纳米结构材料的绿色制备与生物活体标记研究。通过在纳米晶内/外部引入功能化材料，有效增加发光中心的数量或能量传递的效率，提升上转换材料的荧光强度，调控不同组分功能的集成，推动其在生物医学领域的应用。

中文关键词： 稀土发光材料；水溶性；上/下转换发光；生物标记；多模荧光探针

英文摘要： Biomedical imaging technology is the most important tool and research interest of modern medicine and molecular biology for bio-vivo study. It is crucial for disease detection, analysis and early prevention. The major bottleneck restricting the development of the field is the interference of biological tissue fluorescence and luminous intensity of labeled probe materials. Based on the unique upconversion luminescence of rare earth materials, this project investigates the properties and application of rare earth fluoride based upconvertion materials, develops the green synthetic approach for monodisperse rare earth fluoride nanocrystals. Around high fluorescence intensity of the rare earth upconversion luminescence materials under the low excitation density, the project also includes the preparation of multi-functional upconverting composite nanomaterials and their applications for bioimaging. The number of luminescence centers or energy transfer efficiency will increased effectively by inner/outer introducing the functional materials, thus enhancing the fluorescence intensity. The results of research project will regulate the integration of the different component functions, and provide a new and efficient upconversion material system for the bio-imaging applications.

英文关键词： Rare earth luminescent materials；water soluble；up/downconversion luminescence；bioimaging；multimode fluorescent probe