近红外激光触发的核壳结构的复合光催化剂的合成及应用于药物输送与癌症光动力治疗的研究

项目名称： 近红外激光触发的核壳结构的复合光催化剂的合成及应用于药物输送与癌症光动力治疗的研究

项目编号： No.21503175

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 有机化学

项目作者： 许清池

作者单位： 厦门大学

项目金额： 22万元

中文摘要： 以近红外激光为光源，纳米材料应用于癌症药物输送及癌症光动力治疗是一种有效治疗癌症的新方法。本项目拟合成基于上转换纳米颗粒及纳米光催化剂的核壳结构的复合光催化剂，并以人体可接受的近红外激光（≤360 mW/cm2）为光源，研究复合光催化剂在药物输送及癌症光动力治疗的应用。本项目将采取两种手段来提高复合光催化剂的药物输送及癌症光动力治疗的效率：（1）控制上转换纳米颗粒的结构、晶型、粒径及稀土掺杂，从而增强上转换产生的紫外光或可激发光催化剂的可见光的光强度；（2）控制光催化层厚度、选择适当光催化剂、添加贵金属或对光催化剂进行修饰，从而提高光催化剂层产生活性自由基（ROS）的效率。探索贵金属对复合光催化剂的协同促进作用。本项目研究有利于促进纳米材料实际应用于癌症治疗方面的发展。此外，本项目学科交叉性强，通过项目实施可为近红外激光激发的复合光催化剂的合成及其应用于药物输送和癌症光动力治疗提供重要指导

中文关键词： 近红外激光；光动力治疗；药物输送；癌症治疗；光催化

英文摘要： The application of nanomaterials in drug delivery and photodynamic therapy using Near Infrared (NIR) laser as light source is considered as a new and effective method for cancer therapy. In this project, core-shell structure composited photocatalyst based on upconversion nanoparticles (core) and nano photocatalyst (shell) will be developed. Then the composited photocatalyst will be studied for its applications in drug delivery and photodynamic therapy for cancer using human body acceptable NIR laser (≤360 mW/cm2) as light source. Two methods will be used to improve the efficiencies of drug delivery and photodynamic therapy for cancer: (1) enhance the light intensity of the upconversion emission of UV light or visible light (the part of visible light which is able to activate the photocatalyst) by controlling the structure, crystallization, particle size and rare earth metal doping of the upconversion nanoparticles; (2) improve the active free radical (ROS) generation efficiency of photocatalyst layer by controlling the thickness of photocatalyst layer, choosing appropriate photocatalysts, adding noble metal nanoparticles or modifying photocatalyst. Especially, we will investigate the synergistic effects of adding noble metal nanoparticles in the composited photocatalyst. The outcomes of this project will help to promote the practical application of nanomaterials in cancer therapy. Additionally, this project presents strong interdisciplinary and it will provide important guidance for the synthesis of NIR-active composited photocatalyst and its applications in drug delivery and photodynamic therapy for cancer.

英文关键词： Near Infrared;Photo Dynamic Therapy;Drug Delivery;Cancer Therapy;Photocatalysis