基于个体化心血管系统耦合模型的中心动脉压形成机制与无创检测研究

项目名称： 基于个体化心血管系统耦合模型的中心动脉压形成机制与无创检测研究

项目编号： No.61501070

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 无线电电子学、电信技术

项目作者： 肖汉光

作者单位： 重庆理工大学

项目金额： 21万元

中文摘要： 中心动脉压与心血管事件密切相关，是心血管风险评估和降压治疗的重要参考指标。尽管中心动脉压的无创检测技术已取得长足进步，但是，其通用性、实时性、准确性等方面仍存在不足，成为制约该项技术推广应用的主要瓶颈。本项目以个体化中心动脉压测量为研究对象，通过临床试验和数值模拟，对中心动脉压的产生、形成规律及决定因素进行血流动力学的基础科学研究。具体内容包括：心血管系统的结构和力学参数的统计学分析；个体化心血管系统0D-1D耦合模型的建立、个体化参数估计、模型求解与血流动力学仿真研究；基于模型的个体化转换函数的定量表达、中央动脉压计算与校准技术的理论分析。从而，揭示心血管系统与脉搏波之间的相互作用机制，及其对中心动脉压的形成和波形特征的影响规律，探索个体化建模与参数优化技术相结合检测CABP的可行性和有效性，为CABP检测提供一种新思路和新方法，为改进现有CABP无创检测方法和技术提供科学依据。

中文关键词： 血压测量；血流动力学模型；压力脉搏波检测；压力波形

英文摘要： Central aortic blood pressure (CABP), closely related to cardiovascular events, is an important reference index for the assessment of cardiovascular risk and the therapy of hypertension. Although the noninvasive technology of the CABP detection has achieved great advances, there are still some defects and limitations in universality, real-time, accuracy, etc. They have become the main bottleneck which is restricting the popularization and application of the technology. This project, by clinical test and numerical simulation, mainly focuses on the basic scientific research of hemodynamics in the origination, formation and determinants for CABP detection. The detail research include: the statistical analysis of structural and mechanics parameters of cardiovascular system; the modeling of individualized 0D-1D coupled cardiovascular system model, the individualized parametric estimating of the model, the solving of the model and the hemodynamic simulation; the model-based quantitative expression of individualized transfer function, theoretic analysis of CABP calculation and calibration. The study will reveal the interaction mechanism between cardiovascular system and pulse waveforms and its effect on the formation and wave characteristics of CABP, and explore the feasibility and effectiveness of the CABP detection method by combining the individualized modeling and parameter optimization technique, in order to provide a new idea and method for CABP detection and scientific evidence for the improvement of the present CABP noninvasive detection methods and techniques.

英文关键词： Blood pressure detection;Hemodynamic model;Pluse wave detection;Pluse waveform