新型磺酰脲分子多功能生物活性的基础研究

项目名称： 新型磺酰脲分子多功能生物活性的基础研究

项目编号： No.21272129

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 李正名

作者单位： 南开大学

项目金额： 80万元

中文摘要： 磺酰脲类除草剂具有超高效，用量极少，对温血动物几乎无毒，对环境友好的优点，具有绿色农药的特色，在近二十年来一直是研究的热点之一。含单取代嘧啶环的磺酰脲类是我们的发明专利，已从实践中验证其超高效的除草活性。近期我们合成的新磺酰脲类化合物生测表明除具有较好的除草活性外，也具有优异的抗菌活性，可作为先导化合物开展深入研究。同时，磺酰脲类除草剂的残留期调控研究对于开发符合我国国情的除草剂研究具有重要意义。据此，本课题将深入开展新磺酰脲类化合物的分子设计、合成以及除草、降解、抗菌的多功能生物活性研究；建立或完善模拟残留期及多功能生物活性测定方法；总结构效关系规律。本课题的开展将为磺酰脲类化合物的在多领域广泛深入研究奠定基础。

中文关键词： 磺酰脲；抑菌活性；降解；除草活性；合成

英文摘要： Sulfonylurea herbicides are environmental benign herbicides which have been one of the hot research topics in recent decades because they have exhibited extremely low mammalian toxicity and ultra-high efficacy, ultra-low application rates and low environmental impact. Sulfonylurea herbicides containing mono-substituted pyrimidine moiety are orgianted from our invention and have been verified for years of field practices to retain the favourable characteristics as mentioned above. To advance our research interests, more novel sulfonylurea structures have recently been synthesized in our group among which some showed not only good herbicidal activity, but surprising impressing fungicidal activity. Meanwhile, the study on the residue regulation of sulfonylurea herbicides has significant importance to discover new sulfonyl urea herbicide to meet the special crop cultivation pattern (multiple crops on the same piece of land annually) existing in China . Accordingly the project will also cover the basic study on the molecular design, synthesis and multifunctional biological activity (herbicide, degradation, fungicide,sterilizer) of new sulfonylureas; establish or optimize the specific methods of sulfonylure degradation duration and multifunctional biological activitiesy; summarize the structure-activity relationsh

英文关键词： sulfonylurea；fungicidal activity；degradation；herbicidal activity；synthesis