乳腺癌结合抗血管生成和放疗联合治疗的数值模拟和动物实验研究

项目名称： 乳腺癌结合抗血管生成和放疗联合治疗的数值模拟和动物实验研究

项目编号： No.11502146

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 赵改平

作者单位： 上海理工大学

项目金额： 20万元

中文摘要： 抗血管生成靶向药物治疗是新兴的乳腺癌治疗手段，高度特异性、毒副反应小、耐药性好，但单纯靶向药物治疗效果并不十分理想，联合靶向药物与放射治疗成为乳腺癌治疗的新策略，其机制尚不清楚。本项目拟应用生物建模、CFD数值方法、MRI检测技术和动物实验手段相结合，研究新型靶向药物贝伐单抗(Bevacizumab)联合放射治疗乳腺癌后，乳腺癌微血管网结构功能的正常化、血管生长的抑制规律、血管力学特性的改变、微循环内血液灌注特点、局部氧供状况、微环境内组织间质液流动特性、营养药物输运、乳腺癌的增敏效应以及微环境变化规律的抑制机理，为临床乳腺癌诊断和治疗的生物力学机理研究、联合治疗方案设计以及新型靶向药物的筛选打下理论基础。

中文关键词： 乳腺癌；联合治疗；抗血管生成；放射治疗；抑制效应

英文摘要： Antiangiogenic targeting agents therapy shows high specificity, low toxicity and minimal drug-resistant, which is a promising and new measure of breast cancer treatment. Investigations indicate that tumor cures are limited when these agents are used as the sole method of treatment. Combined treatment with these agents and ionizing radiation for breast cancer is a new strategy, but the mechanisms of interaction between antiangiogenic targeting agent and radiotherapy are not full understood. This term combines antiangiogenic targeting agent bevacizumab and radiotherapy for breast cancer to research the inhibition mechanisms and radiosensitization between agent and radiation by using the combination method of biomechanical model, CFD, MRI and animal experiment. The main research contents include: normalization of the vasculature, inhibition of breast cancer angiogenesis, microvessels permeability and function properties, oxygenation changes, nutrition transport and drug delivery, blood perfusion and interstitial fluid flow in the microcirculation, and inhibitory mechanism between increasing the radiosensitivity and microenvironmental factors in the breast cancer. These researches may provide theoretical foundation for the diagnosis and treatment of breast cancer, optimal scheduling of combined treatment and the filter of antiangiogenic targeting drugs for further clinical research of combination therapy.

英文关键词： breast cancer;combination therapy;antiangiogenesis;radiotherapy;inhibition effects