基于氢键作用的溶剂响应型可降解高分子形状记忆纳米复合材料的研究

项目名称： 基于氢键作用的溶剂响应型可降解高分子形状记忆纳米复合材料的研究

项目编号： No.51203130

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 有机高分子材料学科

项目作者： 郑晓彤

作者单位： 西南交通大学

项目金额： 25万元

中文摘要： 溶剂响应型形状记忆高分子复合材料是一种新型刺激驱动形状记忆材料，受到水、湿气或有机溶剂等小分子的刺激，不需要外界再赋予热、磁等刺激条件，表现出更适用于人体的生理环境。但是，目前报道的溶剂响应型形状记忆高分子复合材料不能兼具形状记忆性、功能性和生物相容性等性能。因此，本项目以可生物降解的聚己内酯（PCL）、聚乳酸（PLA）聚合物和葡萄糖改性的磁性功能四氧化三铁（Fe3O4）纳米粒子为原料，通过化学交联或物理混合，制备得到溶剂响应形状记忆效应的可生物降解PCL/PLA/Fe3O4纳米复合材料。同时，揭示出纳米复合材料在生理环境中的形状记忆响应机理，证实PCL、PLA和Fe3O4三种组分之间的氢键作用以及对产生形状记忆效应所起的作用，阐明制备溶剂响应形状记忆性能的可生物降解纳米复合材料的普遍规律。本研究将对形状记忆复合材料在生物医学领域的发展和应用提供科学思路。

中文关键词： 溶剂响应；形状记忆；生物降解；纳米复合材料；响应机理

英文摘要： Solvent-responsive shape memory polymers (SMPs) composite is a new type of stimulus-drived shape memory materials (SMMs), which can switch between temperary shape and original shape upon exposure to an external stimulus of micromolecule such as water, moisture or organic solvent instead of heat, magnetic fields, etc. So that solvent-responsive SMPs composite show the more adaptability in physiological environment of the human body than other stimulus- responsive SMPs composite. However, recent reports show that solvent-responsive SMPs composite can't meet the needs of shape memory effect, functionality and biocompatibility completely. For this reason, the biodegradable PCL/PLA/Fe3O4 nanocomposites with solvent-responsive shape memory effect consisted of biodegradable poly(?-caprolactone) (PCL), poly (D, L-lactide) (PDLLA) and magnetic iron oxide (Fe3O4) nanoparticles modified by glucose are prepared by chemical crosslinking or physical compounding in this study. Moreover, the shape memory effect machanism of nanocomposites in physiological environment will be revealed, the roles of PCL, PDLLA and Fe3O4 on shape memory effect of nanocomposites and their hydrogen bonding interaction will be demonstrated and the prepared principle of the biodegradable nanocomposites with solvent-responsive shape memory effect will

英文关键词： solvent-responsive；shape memory；biodegradable；nanomaterials；response mechanism