新型化学发光试剂/催化剂双功能化纳米材料及其在体外诊断中的应用研究

项目名称： 新型化学发光试剂/催化剂双功能化纳米材料及其在体外诊断中的应用研究

项目编号： No.21475120

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 崔华

作者单位： 中国科学技术大学

项目金额： 100万元

中文摘要： 本项目拟探索新的合成方法，制备具有优良化学发光特性的化学发光试剂/催化剂双功能化的金属和碳纳米材料；对其表面性质、化学发光特性、异相催化特性及机理进行研究；针对体外诊断中的痕量分析物，研究具有高强度化学发光信号的分析探针和分析界面的可控组装及纳米界面上光、电化学性质的分子调控机制，设计新型的组装策略，发展基于标记技术和无标记技术的化学发光分析新方法，实现多种物质的高灵敏度、高选择性、快速、低成本检测，为体外诊断提供新的有效的技术手段。此项工作创新性提出了化学发光试剂/催化剂双功能化纳米材料的研究思路和方法，探索固载于纳米表面的催化剂对液相化学发光反应的异相催化特性和双功能化纳米材料的化学发光特性，将进一步丰富人们对纳米材料特殊的物理化学性质的认识，对于纳米科学、催化科学和化学发光的基础理论研究具有重要的意义。基于双功能化的纳米材料发展的化学发光分析新方法，在体外诊断中具有重要的应用潜力。

中文关键词： 化学发光；催化剂；双功能化纳米材料；体外诊断

英文摘要： Despite much progress in functionalized nanomaterials with novel magnetic, surface-enhance Raman scattering, localized surface plasmon resonance, fluorescent, phosphorescent, catalytic and biological properties, chemiluminescence (CL) functionalized nanomaterials with high CL efficiency are far from fully developed. The project is to explore new methodologies for the synthesis of CL reagent/catalyst bifunctionalized metal nanomaterials and carbon nanomaterials with high CL efficiency. The surface properties, CL properties, heterogeneous catalytic properties and their mechanism of the synthesized bifunctionalized nanomaterials are to be studied. Highly chemiluminescent analytical probes and analytical interface are to be designed and assembled by using bifunctionalized nanomaterials as building blocks. The molecular regulation mechanism of the CL and electrochemical properties on the nano-interface are to be studied. Novel CL analytical methods based on labeling technology or label-free technology are to be established for sensitive, selective, rapid and low-cost detection of trace amount analytes. This work is for the first time to explore the synthesis of CL reagent/catalyst bifunctionalized nanomaterials and provides a new class of functionalized nanomaterials with excellent CL activity. The disclosure with respect to heterogeneous catalytic property of catalyst immobilized on the surface of nanomaterials in liquid-phase CL reactions, unique CL properties of bifunctionalized nanomaterials and their mechanisms will further enrich our knowledge on the unique physicochemical properties of nanomaterals. It is of great importance for fundamental studies of nano-science, catalytic science and CL. Finally, this work is expected to provide effective analytical technique for in vitro diagnostic and will be of great application prospect.

英文关键词： Chemiluminescence;Catalyst;Bifunctionalized Nanomaterials;In Vitro Diagnosis