辨证选用中成药的辅助决策模型研究

项目名称： 辨证选用中成药的辅助决策模型研究

项目编号： No.81202775

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 医学八处

项目作者： 白文静

作者单位： 中国中医科学院中医临床基础医学研究所

项目金额： 23万元

中文摘要： 中成药以"疗效确切、服用便捷、使用安全"等优势深受广大患者青睐，在临床实践中被西医医师广泛应用。但西医医师往往不具备中医辨证论治理论知识，使用中成药时盲目性较大，导致近年来因不合理用药产生的安全事件逐年增多，这已成为影响中成药疗效评价、甚至危及用药安全的重大问题。提高西医医师选用中成药的准确性是目前临床亟待解决的问题，也是促进中成药合理化使用关键环节。 中成药的研制与应用是以针对特定人群能够取得最大治疗效应为前提的，中医临床专家根据患者临床四诊信息和生物学指标，方证对应地选择中成药的思维过程，是一个统计判别过程。基于此，本课题拟采用项目反应理论、选择性集成分类器等技术建立易于为西医医师理解和操作的临床信息采集标准；构造富集中医辨证选药经验，能够再现中医思维下临床辨证信息与中成药之间的对应关系的数学模型，用于辅助西医医师正确决策用药，为安全、有效、规范地使用中成药提供技术支撑。

中文关键词： 辅助决策；项目反应理论；中成药；特征选择；

英文摘要： Proprietary Chinese medicine，which is effective, safe and easy to use, is favored by patients. Itis often used not only by TCM doctors but also by Western medicine physicians.who are usually lack of TCM theory. The blindness in the use of proprietary Chinesemedicines resulted in more and more adverse events in recent years which hasbecame a major issue affecting the efficacy evaluation of proprietary Chinesemedicines or even endangering the safety of drugs. Improving the accuracy ofWestern doctors' use of proprietary Chinese medicines is a problem need to besolved and is also a key link to promote the proper use of traditional Chinesemedicine.Webelieve that achieving the maximum treatment effect is the prerequisite of thedevelopment and application of proprietary Chinese medicines. For TCM clinicalexperts, the process of proprietary Chinese medicine selection, based on fourdiagnostician information and biological indicators, is a Statistics Assessmentprocess. Based on this, we are going to establish a clinical informationcollection standard which is easy to understand and operate by Medical Doctorswith item response theory and selective integration classifier technology.Amathematical model, which includes TCM doctors' experience and could embody therelation between four diagnostic information and proprietary Chi

英文关键词： decision-making；item response theory；Chinese patent medicine；feature selection；