铜银金团簇与DNA碱基的相互作用

项目名称： 铜银金团簇与DNA碱基的相互作用

项目编号： No.21273246

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 郑卫军

作者单位： 中国科学院化学研究所

项目金额： 86万元

中文摘要： 为了实现纳米材料的应用，人们开始利用DNA 及其片段的分子识别能力来对金属纳米颗粒(如：铜、银、金纳米团簇)进行可控自组装。组装过程中的一个关键因素是纳米颗粒与DNA碱基的相互作用，同时，由于自组装功能化材料在生物和医药方面有着潜在的应用，它们的生物安全性受到很大关注。深入认识铜银金团簇与DNA 碱基的相互作用，对于实现这些金属纳米材料的可控自组装、以及了解组装而成的功能化材料的生物安全性具有重要意义。我们计划在高真空气相条件下产生铜、银、金团簇，研究这些团簇与DNA 碱基的反应以及反应过程中所产生的复合物，运用飞行时间质谱、激光解离、光电子能谱等手段来研究铜银金团簇―DNA 碱基复合物的结构和性质，从而认识这些团簇与DNA 碱基的相互作用，总结其中的规律，为金属纳米材料的可控自组装提供关键实验数据和理论依据。

中文关键词： 金属团簇；DNA碱基；相互作用；自组装；光电子能谱

英文摘要： In order to develop useful nanomaterials, DNA and DNA oligonuleotides have been used for controllable assembling of metal nanoparticles, such as copper, silver, and gold nanoparticles, into macroscopic structures. One important factor that affects the self-assembly of nanoparticles is the interaction between nanoparticles and DNA bases. Besides, the safety of self-assembled functional materials on biological systems has attracted special attention because of their potential applications in biology and medicine. Investigation on the interactions of copper, silver and gold with DNA bases is important for both development of self-assembled materials and understanding the safety of these materials on biological systems. We plan to generate copper, silver and gold clusters under high vacuum condition, to study the reactions of these clusters with DNA bases, and to study the structures and properties of the metal-base complexes using a variety of techniques, such as time-of-flight mass spectrometry, photodissociation, and photoelectron spectroscopy. We hope that will be helpful for understanding the interactions of these metal clusters with DNA bases and will provide valuable information for the development of self-assembled functional materials from both experimental and theoretical point of view.

英文关键词： Metal clusters；DNA bases；Interaction；Self-assembly；Photoelectron