基于能谱CT与碘分布对门静脉高压血流动力学演变规律的研究

项目名称： 基于能谱CT与碘分布对门静脉高压血流动力学演变规律的研究

项目编号： No.81201092

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 影像医学与生物医学工程

项目作者： 赵丽琴

作者单位： 首都医科大学

项目金额： 23万元

中文摘要： 肝硬化失代偿期可引起门静脉高压，但是门静脉高压时肝脏血流灌注与门-体侧枝循环之间相互关系的演变规律尚未阐明。CT增强扫描时含碘对比剂在体内遵循药代动力学规律，我们已据此根据相关生理参数建立了正常肝脏、脾脏及门静脉碘分布的"时间-密度曲线"模型；能谱CT能够获得单能量图像，并可以定量测定被扫描体的碘含量，获取碘对比剂在体内分布的时间-密度曲线，基于上述两点，我们提出依据能谱CT对碘分布的测量可以建立门静脉系统血流动力学模型并对其演变规律进行研究的假设。本研究拟首先应用能谱CT对门静脉系统正常血流动力学模型进行验证后，对行能谱CT增强扫描的肝硬化门静脉高压患者，通过测定不同时相的碘含量获得其时间-密度曲线，与正常模型进行比较、拟合出其相应的血流动力学模型并进行分类后，结合门-体侧支循环的情况，探索门静脉高压患者门静脉系统血流动力学的变化规律，为门静脉高压的治疗提供理论基础。

中文关键词： 门静脉；高血压；血流动力学；能谱CT；定量分析

英文摘要： Portal hypertension is the main complication of cirrhosis. But the developing regulation of portal hypertension between blood perfusion and collateral circulation remains unknown. The iodine concentration in vivo follows the pharmacokinetics law when performing contrast enhanced CT. Thus the mathematic model of iodine distribution time-density curve of normal liver, spleen and portal vein has already been established according to the relevant physiological parameters in our previous study. Dual-energy CT could obtain monochromatic energy, measure the iodine content within the scanning material quantitatively and obtain the time-density curve of iodine contrast media in vivo. On account of the two above, we hypothesized that the hemodynamic mathematic model of portal venous system of cirrhotic patients could be set up with spectral CT and the developing law could be studied by that. Firstly, we plan to validate the normal homodynamic model of portal venous system by spectral CT, then measure the iodine content of different phases and get TDC of cirrhotic patients who underwent enhanced spectral CT scanning. By contrast to the normal modeling, the corresponding homodynamic model could be obtained and classified. Combined to the circumstances of portal-systemic collateral circulation, we could explore the developin

英文关键词： portal vein；hypertension；hemodynamic；spectral CT；quatitative analysis