用于磁靶向肿瘤联合治疗的复合功能稀土纳米材料研究

项目名称： 用于磁靶向肿瘤联合治疗的复合功能稀土纳米材料研究

项目编号： No.51302180

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 程亮

作者单位： 苏州大学

项目金额： 25万元

中文摘要： 纳米生物医学是一门近年来发展非常迅猛的新兴交叉学科，为重大疾病如癌症的检测和治疗提供了全新的机遇。稀土纳米晶独特的上转换发光性能在生物成像中有着广泛的潜在应用，近期也得到了很大的关注。本项目中，申请人拟在前期基于稀土发光纳米晶的活体成像、活体光动力治疗以及复合功能材料的构建等相关工作的基础上，以稀土氟化物纳米晶为基底，构建一系列具有光磁复合功能和药物装载能力的新型多功能复合纳米材料。我们将通过改进材料的尺寸、形貌和表面修饰，以优化其在生物体系中的行为并得到满足生物安全性要求的医用纳米材料，并利用这些材料在动物模型上实现对肿瘤的磁场定位靶向与分子靶向，并通过复合纳米材料装载的光疗和化疗药物对肿瘤进行联合治疗，纳米材料自身的光磁性质将被进一步用于活体内的追踪和治疗过程中的实时显像，以期实现成像模式指导下磁靶向作用下的肿瘤联合治疗，为恶性肿瘤治疗这一重大难题提供新的可能手段。

中文关键词： 稀土上转换纳米材料；功能复合纳米材料；磁靶向；多模态成像；肿瘤联合治疗

英文摘要： Nanomedicine as a multidisciplinary research area has attracted tremendous attention in the past decade, and bring many new opportunities for diagnosis and treatment of various major diseases such as cancer. In the recent few years, rare-earth nanocrystals with unique up-conversion luminescence property have shown great promise for applications in biological imaging and therapy. In this project, based on our previous studies of rare earth upconversion nanoparticles (UCNPs) and their multifunctional composite nanostructures for in vivo imaging and photo therapy, we will design a series of multifunctional nanocomposites with integrated optical and magnetic properties, together with drug loading capacity, for magnetically targeted combined cancer therapy. We will optimize the sizes, morphologies, and surface modifications of our nanocomposites to improve their biocompatibility and minimize their toxicity in biological systems. Enhanced tumor targeting of these multifunctional nanocomposites will be realized afterwards by both magnetic and molecular targeting in vitro and in vivo. After demonstrating each single treatment methodology, the combined cancer therapy will be carried out, aiming at synergistic therapeutic effects of chemotherapy, photodynamic therapy, and / or photothermal therapy. The imaging capability

英文关键词： Upconversion nanoparticles；Multifunctional nanocomposites；Magnetic targeting；Multimodal imaging；Combined tumor therapy