中国人群抑郁障碍与心血管疾病及其主要危险因素的关联研究

项目名称： 中国人群抑郁障碍与心血管疾病及其主要危险因素的关联研究

项目编号： No.81202266

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 预防医学、地方病学、职业病学、放射医学

项目作者： 余灿清

作者单位： 北京大学

项目金额： 12万元

中文摘要： 心血管疾病和抑郁障碍是我国目前以及将来造成沉重疾病负担的主要疾病。在近十几年来，世界各国学者开展了一系列流行病学研究，发现抑郁障碍与心血管疾病存在关联，同时还发现心血管疾病的危险因素存在聚集性，也与抑郁障碍之间存在关联。这些因素包括：高血压、糖尿病、超重与肥胖、吸烟、饮酒、低体力活动等因素。目前国内则很少开展类似的研究，仅有少量研究都是基于医院的小样本研究。本项目拟在中国慢性病前瞻性研究大规模人群队列的基础上，①采用横断面研究分析抑郁障碍与心血管疾病危险因素的关联；②采用病例队列研究设计探索抑郁障碍与主要心血管疾病之间的关联；③采用结构方程模型评价它们之间的病因模型。研究结果能为我国心血管疾病的预防和控制提供科学依据，并为今后的心血管疾病患者中抑郁障碍的筛查和临床治疗提供证据，从而减轻疾病的负担。

中文关键词： 流行病学；心血管疾病；抑郁障碍；脑卒中；糖尿病

英文摘要： Both cardiovascular diseases (CVDs) and depression disorder cause heavy burden in China, and they would be even worse in the future.The association between depression disorder and cardiovascular disease was found in many published articles last decade, meanwhile, the clustering of risk factors of cardiovascular diseases which including hypertension, diabetes, overweight, obesity, smoking and alcohol drinking, is also associated with depression symptom. But few researches has been done in China, all the published articles are hospital-based design with small sample size. Our study is based on the China Kadoorie Biobank (CKB) which is a large cohort with sample size of 50 million from 10 sites all over China. the aims of the study focus on three aspects: A)to explore the epidemiological relationship between depression disorder and cardiovascular disease risk factors with cross-sectional design, B)to examine the relationship between depression and cardiovascular diseases by setting up a case cohort, C) employ the structure equation model to compare different causal model with the data from CKB . The results of this study might provide evidence for chronic disease prevention and control, and support the screening programme and treatment for cardiovascular diseases patients with depression symptoms,so that to the bur

英文关键词： Epidemiology；Cardiovascular disease；Major depression disorder；Stroke；Diabetes mellitus