新型手性P/N配体的设计合成及不对称催化性能研究

项目名称： 新型手性P/N配体的设计合成及不对称催化性能研究

项目编号： No.21262011

项目类型： 地区科学基金项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 段正超

作者单位： 湖北民族学院

项目金额： 50万元

中文摘要： 本项目旨在通过简短的合成步骤，将噁唑啉杂环引入到手性配体的结构中而设计合成一类新型手性P/N配体，通过系统考察磷配位原子上的取代基、配体骨架结构等对不对称催化反应活性和立体选择性的影响，探索该类手性配体的结构与不对称催化反应性能间的关系，总结规律性认识，指导新配体的设计。在新配体的应用研究方面，以烯丙基取代反应为起点，并重点开展这些手性配体在一些具有挑战性的、具有一定难度的不对称催化反应，如高位阻的硝基烷烃与醛（酮）的不对称Herry反应、不对称[3+2]环加成反应以及炔丙醇酯的胺化反应等中的应用，推出具有创新特色的研究成果。

中文关键词： 手性配体；合成；不对称催化；；

英文摘要： As a part of our continuous efforts toward the development of new and practical chiral ligands for use in the asymmetric reaction of challenging substrates, the present project will focus on: 1) the design and synthesis of new chiral P/N ligands which contained a oxazoline backbone and their application in the catalytic asymmetric Herry reaction; 2) the investigation of the relationship between the structure of these P/N ligands and their catalytic activities in the Cu-catalyzed asymmetric Herry reaction; 3) extending the application of chiral P/N ligands in asymmetric catalysis. By comparing the catalytic activities and enantioselectivities of various P/N ligands, the rationale of the relationship between the ligand structure and catalytic efficiency will be summarized and guide the design of new generation of chiral P-ligands. To further extend the application of chiral P/N ligands in asymmetric reaction, some new or challenging substrates will be synthesized and submitted to the catalytic asymmetric Herry reaction with these P/N ligands. The potential use of these P/N ligands in chemical industry will be evaluated. The application of P/N ligands in other challenging catalytic reaction such as asymmetric 1,3-dipolar cycloaddition reaction and asymmetric propargylic substitution reaction will also be examin

英文关键词： chiral ligand；synthesis；asymmetric catalysis；；