用于水体系的可视共振拉曼探针的制备研究

项目名称： 用于水体系的可视共振拉曼探针的制备研究

项目编号： No.21271095

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 夏立新

作者单位： 辽宁大学

项目金额： 80万元

中文摘要： 表面增强拉曼散射（SERS）光谱作为一种超灵敏的分析技术在生命科学领域得到了广泛地关注。SERS探针在生命科学领域中应用的前提之一就是可用于水体系。本项目旨在通过对探针分子和基底的设计合成，实现可用于水体系的可视共振拉曼探针的制备。罗丹明6G（R6G）是理想的共振拉曼探针分子，但是它在贵金属表面吸附能力弱，难以在水体系中应用。本工作利用巯基在金表面吸附强的特点，结合R6G的共振增强拉曼效应，以R6G为母体，设计并合成同侧带有双巯基的新多环芳香化合物，这样通过"双齿"巯基吸附，使其在水体系中能稳定地"锚合"在金基底上，解决R6G等探针分子难以在水体系中应用的问题。又本项目欲建立乳液控制合成核壳材料新方法，通过该法制备以稀土上转换发光材料为核，以金为壳（非完整封闭壳），利用纳米金对内核发光性能的调制，制备可视SERS基底，解决SERS基底示踪难的问题，为其在生命科学领域中的应用带来便利。

中文关键词： 纳米粒子；表面增强拉曼散射光谱；探针；上转换发光；水溶液

英文摘要： Surface-enhanced Raman scattering(SERS) technology is widely used as an analytical tool with high sensitivity in the life science in recent years. The one of preconditions for application in the life science is that SERS probe can be used in aqueous solution. In this work, preparation of visible resonance Raman probe for being used in aqueous solution will be investigated. Rhodamine 6G（R6G）is a good resonance Raman probe molecule. But, it is difficult for R6G to be used in aqueous solution due to the fact that the adsorption capacity of R6G on noble metal surfaces is weak. A novel kind of rhodamine derivative with di-thiol on the same side is designed and synthesized with R6G as its main structure by considering that R6G is a good resonance Raman probe molecule and thiol group should adsorb favorably on noble metal surfaces by forming an M-S bond. The di-thiol terminated rhodamine derivative can still 'anchor' on noble metal surfaces in aqueous solution due to di-thiol as the absorbing groups. Thus, the rhodamine derivative can be used as a probe molecule in aqueous solution. On the other hand, we will establish an emulsion-controlled method for the preparation of core/shell materials. A series of visible SERS substrates are synthesized with rare-earth-element-doped upconversion nanocrystals as core and gold nan

英文关键词： nanoparticle；surface-enhanced Raman scattering；probe；up conversion fluorescence；aqueous solution