精神分裂症视听感觉整合缺陷的ERP机制及其与精神症状的相关性

项目名称： 精神分裂症视听感觉整合缺陷的ERP机制及其与精神症状的相关性

项目编号： No.31200844

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 认知的脑结构与神经基础

项目作者： 刘涛生

作者单位： 中国人民解放军第二军医大学

项目金额： 20万元

中文摘要： 精神分裂症(SZ)是一种常见而病因未明的精神障碍，后期社会功能衰退明显，给患者家庭及社会带来沉重负担，由于其无法根治性，对其症状发生机制的研究课题一直具有重要意义。其中,SZ多感觉整合尤其视听感觉整合的潜在缺陷与症状发生的关系逐渐成为当前新兴研究热点，但目前SZ视听感觉整合缺陷的本质、发生阶段及范围广度远未被阐明。我们基于以往对正常健康人情绪性视听线索整合加工的研究，拟利用具有高时间分辨率的ERP技术，使用简单或复杂视听刺激全方位地动态考察SZ对简单刺激、面孔人声以及情绪性线索的视听感觉整合潜在缺陷及其发生的加工阶段，以加深对SZ视听感觉整合缺陷本质的理解，同时结合PANSS及SDSS量表评定，以探索SZ多感觉整合缺陷与患者临床症状包括社会功能状态的相关性。本项目的开展将可以弥补当前SZ视听感觉整合加工神经机制研究的匮乏，有助于加深对SZ症状发生机制的理解，为将来可能的治疗提供实证基础。

中文关键词： 精神分裂症；多感觉整合；事件相关电位；面孔声音加工；

英文摘要： In the world, about 1 in every 100 persons will develop schizophrenia in their lifetime, and the patients with schizophrenia often end in poor social functioning, which would bring a heavy burden on the patients' family and society. It's significant to do the research about the mechanism of the psychiatric symptoms insofar there is no fundamental solution for schizophrenia. Most events in the natural environment generate stimulation to several modalities, which requires the brain to integrate a variety of different inputs from sense organs into a single percept of the situation. Give Schizophrenia is characterized by 'split of mind', we posit that deficit in multisensory integration (MSI) should contribute to the form of the psychiatric symptoms in schizophrenia. Recently, the researchs of deficit in MSI in schizophrenia and the relationship between the deficit and the psychiatric symptoms have been booming, however, the nature, impaired cognitive stage and span for the MSI deficit in SZ were far from understood. Our previous study on audiovisual integration of emotional cues from face and voice in the healthy subjects showed that the MSI effect of emotional cues occurred as early as 200 ms post-stimuli. Base on our previous studies, this time we wanted to focus on the deficit in MSI in schizophrenia. In this p

英文关键词： Schizophrenia；multisensory integration；event related potentials；face-voice processing；