可更新、多功能微流控芯片平台的研究与应用

项目名称： 可更新、多功能微流控芯片平台的研究与应用

项目编号： No.20805011

项目类型： 青年科学基金项目

立项/批准年度： 2009

项目学科： 生物科学

项目作者： 王爱军

作者单位： 河南师范大学

项目金额： 20万元

中文摘要： 本研究合成了多种功能磁核/壳纳米材料，并详细研究了其相关特性，探索了将其作为固定相构建可更新、多功能的微流控分析平台。采用芯片-磁控方法，探索了其在手性分离、生物分子的分离,以及蛋白质、环境污染物富集等方面的应用。该方法可以拓展磁性功能材料的应用领域，易与不同的检测模式进行联用；并且磁性柱易于填充和更新。实验发现芯片管道尺寸是影响芯片-磁控联机性能的关键因素之一，直接影响磁柱的尺度，进而影响分离效率、分离度以及分离通道电流，这一点仍需要做进一步的深入研究。后来，研究内容作了部分调整，充分利用该实验合成平台来制备树枝状的纳米金和纳米铜、单分散的铂纳米球、核壳结构的银-聚多巴胺杂化材料、空心的银-聚多巴胺杂化材料、MnO2纳米棒、空心花状ZnO、空心双笼ZnO、空心Cu/Cu2O、八角对称树枝状的PbS和空心四面体框状的PbS等微/纳光电材料，并利用搭建的光电检测平台详细研究了这些材料的光催化和电催化性能。目前共发表论文22篇，其中SCI论文14篇，影响因子大于3.0的论文有7篇。

中文关键词： 微流控分析；磁柱；核/壳纳米材料；光电材料

英文摘要： In this research, we have prepared several well-defined magnetic core/shell nanomaterails and investaged their related properties. We have tried to use these magnetic core/shell nanomaterails as solid stationary phases for the fabrication of renewable multifunctional microfluidic scaffolds. We have studied the chiral separation, biomoleculars separation, and proteins preconcentration using the microfluidic chip coupled with the magnetic control technology. The as-prepared multifunctional materials have potential applications, and easily couple with a variety of detection modes. The nano-magnetic column can be easily constructed and retained within a microfluidic flow using a local magnetic field. The column can be be simply packed without any special layout, and renew. Evidently, the size of the microfluidic channels is key factor for the microfluidic chips coupled with the magnetic control technology. It has great effects on the separation efficency, separation resolution, and separation channel current. Much work still needs to be done about this issue. Laterly, we partly adjusted the research plan by using this fabraction materails scaffolds, and constructed several novel optical/electronic materials, including Au nanodendrites, Cu dendrites, monodispersed Pt nanoparticles, core/shell Ag-polydopamine hybrid structures, hollow Ag-polydopamine materails, MnO2 nanorods, hollow ZnO flowers, hollow double-caged peanut-like ZnO,hollow Cu/Cu2O microspheres, octa-symmetric-dendritic arms PbS. Meanwhile, more attentions have been focused on the inverstations of their optical,electronic, and catalytic properties. By far, we have published 22 papers, including 14 SCI papers. Among them, the influnence factor of 7 papers are above 3.0.

英文关键词： Micro total analysis system; Magnetic column; Core/shell nanoparticles; optical/electronic materials