高效液相色谱法应用于金纳米粒子形成机理的研究

项目名称： 高效液相色谱法应用于金纳米粒子形成机理的研究

项目编号： No.21305082

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 张彦

作者单位： 山西大学

项目金额： 25万元

中文摘要： 精确控制尺寸和形貌是制备高性能金纳米粒子（Au NCs）的关键，通过控制反应条件制备的Au NCs仍存在一定的尺寸分布问题，为进一步改进制备技术或开发新技术，Au NCs生长机理的研究非常重要。分离技术的应用可得多种单一尺寸的金纳米粒子，本项目采用HPLC技术将不同方法制备的Au NCs产物进行分离，结合多种表征手段对分离得Au NCs进行分析测试，并采用HPLC方法对金纳米粒子的制备过程进行实时监测，研究不同反应条件对Au NCs尺寸、金原子/配体数目分布的影响，全面研究不同尺寸的Au NCs随反应条件的变化，较详细、准确地揭示Au NCs的微观生长机理，促进Au NCs可控制备的发展，使Au NCs更有效地应用于材料、生物、医学及毒理学等领域。通过HPLC分离还可同时得不同尺寸、含有不同金原子/配体数的Au NCs，满足对微观结构有较高要求的精密器件、微型催化等的需要。

中文关键词： 金纳米粒子；高效液相色谱；形成机理；分析应用；

英文摘要： Nowadays synthesis of gold nanoclusters (Au NCs) focuses on the precise control of size, shape and surface chemistry. However, there are still size range to a certain extent of Au NCs although the reaction conditions are controlled quite accurately and carefully. The complexity of the synthesized Au NCs is so great that separation approachs have been used to achieve numerous single size Au NCs. In order to obtain monodisperse Au NCs, improving synthesis technology or developing new method is also very important, which imply that the study of the growth mechanism of Au NCs is extremely significative. In this work, high performance liquid chromatography (HPLC) is employed to separate Au NCs protected by monolayer ligand, which synthesized by different methods. The Au NCs fractions will be fully characterized by UV-vis absorption spectroscopy, fluorescence spectroscopy, high resolution transmission electron microscopy, thermogravimetric analysis, and mass spectroscopy. The number of Au atoms and ligand is identified. And the information about the size and photometric characteristics of Au NCs can be also obtained. The proposed HPLC methodology will be applied to investigate the synthesis of AuNCs in real time. And various polydisperse Au NCs synthesized from different experimental conditions such as the type of red

英文关键词： Gold Nanoclusters；High Performance Liquid Chromatography；Growth Mechanism；Analytical application；