图像引导术中放疗方法研究

项目名称： 图像引导术中放疗方法研究

项目编号： No.11475261

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 戴建荣

作者单位： 中国医学科学院肿瘤医院

项目金额： 74万元

中文摘要： 术中放射治疗（IORT）是多种肿瘤疾病的主要治疗方式之一，由于缺少三维影像和剂量分布信息，目前仅凭肉眼观察和经验设定治疗参数，这种方法存在较大安全隐患。此外，因无法实现术中与术后放疗的三维剂量叠加，也会影响术后放疗的效果。本项目拟将外照射放疗中图像引导定位和三维治疗计划方法运用到IORT上来，建立图像引导术中放疗方法。通过获取术前CT/MRI图像，导入放疗计划系统，进行IORT方案模拟，给出手术路径和切除范围，评估不同方案对肿瘤和各个器官所受剂量的影响，确定IORT预计划；根据预计划放置模拟限光筒，获取术中CT/MRI/超声图像，融合配准后导入计划系统，根据解剖结构变化和实时剂量分布，快速修正IORT计划；获取术后CT/MRI图像，与术中图像进行变形配准，考虑放射生物学效应，合成术后和术中放疗剂量分布。研究成果有助于提高外科学与放疗科学的交叉互融程度，推动IORT进入图像引导的精确放疗时代

中文关键词： 术中放疗；图像引导；治疗计划设计；多模态图像配准；变形配准

英文摘要： Intraoperative radiation therapy(IORT) has been widely used for cancer treatment. For lack of information of three demention image and dose distribution in IORT, it is not safe and reasonable enough to setup treatment parameters only by observation and personal experence.Additional, due to without calculation of the three dimension dose distribution combining intraoperative with postoperative radiotherapy, the accuracy of postoprative radiotherapy may be impeded to some extent also. This project is going to apply the techniques of image guided radiation therapy and three dimension treatment planning from external radiotherapy to IORT, as well as archieve image guided radiation therapy for IORT. The project contents are as followed: acqueiring CT/MRI images before operation, importing images to treatment planning system, simulating IORT treatment modality, determining surgery path and excision extension, evaluating and comparing dose delivery on target and organs in different trials, confirming final IORT plan; seting up simulation applicator according to the plan, acquiring introperative images of CT/MRI/ultrasound, proceeding multimode images registration and fusion, in terms of organ changes and dose distribution modifying IORT plan timely; deformable registration for intraoperative and postoperative CT/MRI, integrating dose distribution for intraoperation and postoperation based on radiation biology. The project outcome will improve crossover and integration for surgery and radiation oncology, and bring IORT to accurate radiotherapy era.

英文关键词： IORT;IGRT;Treatment Planning;Multimodality Image Registration;Deformable Registration