青少年抑郁的自动情绪调节的神经机制研究

项目名称： 青少年抑郁的自动情绪调节的神经机制研究

项目编号： No.31470997

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 神经、认识与心理学

项目作者： 张文海

作者单位： 盐城工学院

项目金额： 82万元

中文摘要： 针对青少年抑郁研究中的前沿热点，本项目在前期已有研究的基础上,借助于ERP、结构MRI和静息态fMRI手段，探讨青少年抑郁的自动情绪调节的认知神经机制。本项目拟回答以下科学问题：(1)如何通过ERP手段揭示青少年抑郁在自动情绪调节不同阶段的正负偏向缺陷？(2)青少年抑郁的脑结构-功能异常变化与自动情绪调节存在怎样的关系？因此，本项目首先从自动反应抑制、自动认知控制两个不同阶段，考察青少年抑郁的正负偏向的时间加工过程。其次，采用VBM测量和静息态fMRI，考察青少年抑郁的皮层灰质体积、内在功能连接的异常变化；采用连接组学方法，探索青少年抑郁的脑结构和功能拓扑特征的异常变化。继而分析了这些结构-功能的异常变化与自动情绪调节ERP成分的关系。本项目将有助于更全面地认识青少年抑郁的自动情绪调节的神经机制，为青少年抑郁的早期诊断和预防提供理论基础，也将促进连接组学方法在我国青少年脑发展研究中的应用。

中文关键词： 青少年；自动情绪调节；事件相关电位；脑机制；连接组学

英文摘要： In view of the frontier issues in the study of adolescent depression,the present research will be based on pilot studies and apply ERP,structural MRI and resting-state fMRI to explore the cognitive neural mechanism of automatic emotion regulation in depressive adolescents. We will answer the following scientific problems: (1) using ERPs, how can we reveal positive and negative deficits at different processing stages of automatic emotion dysregulation in depressive adolescents; (2) what relationships are there between abnormal changes in the stuture and function of depressive adolescent brains and ERPs reflecting automatic emotion regulation? This research will first examine time course of positive and negative biases in depressive adolescents from the aspects of automatic response inhibition and automatic cognitive control. Next, this project will use voxel-based morphometry and resting-state fMRI to investigate abnormal changes in gray matter volume and intrinsic function connectivity of depressive adolescents, and use graph-theory-based connectomics to explore brain topographic abnormal changes in depressive adolescents from the structural and functional aspects. Furthermore, we will analyze the correlation between these structural-functional abnormal changes and ERPs reflecting automatic emotion regulation. This project will contribute to a more comprehensive understanding of the cognitive neural mechanism of automatic emotion regulation in depressive adolescents,serve as a theoretical underpinning of early diagnosis and prevention of adolescent depression,and promote connetomics deeper into the development research of adolescent brain in China.

英文关键词： adolescent;automatic emotion regulation;event-related potential;brain mechanism;connectomics