均相/非均相Au,Pd催化酯的C-O键活化反应研究

项目名称： 均相/非均相Au,Pd催化酯的C-O键活化反应研究

项目编号： No.21462031

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 包永胜

作者单位： 内蒙古师范大学

项目金额： 50万元

中文摘要： 本课题拟采用一系列0价钯，2价钯配合物以及负载纳米Au,Pd做催化剂，利用酯作为环境友好，原子经济的碳源，研究均相Pd催化酯的C-O键活化反应以及非均相催化酯的C-O键活化反应，实现可循环的绿色催化反应。同时通过分离反应中间体、测定反应前后催化剂的价态变化等方法，对比研究两种体系的催化反应机理，探究Au,Pd催化反应的根本规律。研究并实现多种导向酯的酰基C-O键活化反应，并尝试含有Sp3 C-O键的烷基酯的金属催化反应。此外，利用已发现的新反应，进行应用性研究，如金鸡纳碱的改性。此项目对C-O键的活化反应研究，对Au,Pd金属有机化学的深入扩展以及酯化学的发展具有重要的意义和价值。

中文关键词： Au；；Pd催化；C-O活化；酯；均相；非均相

英文摘要： Used a series of palladium(0), palladium(II) complexes and supported nano Au, Pd as catalysts, esters as environmentally benign and atom-economical carbon sources, homogeneous palladium catalyzed C-O bond activated reaction and heterogeneous catalyzed C-O bond activated reaction of the ester would be researched for achieve recyclable green catalysis reaction. Meanwhile, this project will comparative study the catalytic reaction mechanism of two kinds of systems and explore the foundamental law of Au, Pd catalyzed reaction by means of isolated reaction intermediates and tested the valence state changes of fresh and used catalysts. Many kinds of directed acyl C-O activated reaction of ester would be studied and realized. The metal catalyzed reaction of alkyl ester which containing sp3 C-O bond would be tried. In addition, the applied research of discovered novel reaction, for instance, the modification of cinchona alkaloid would be conducted. This project has important significance and value to the C-O activation reaction study, the deepen and extension of Au, Pd metal-organic chemistry and the development of ester's chemistry.

英文关键词： Au;Pd catalyzed;C-O activation;ester;homogeneous;heterogeneous