稳态强磁场下细胞凋亡的多基因调控机制研究

项目名称： 稳态强磁场下细胞凋亡的多基因调控机制研究

项目编号： No.U1232144

项目类型： 联合基金项目

立项/批准年度： 2013

项目学科： 物理学II

项目作者： 许安

作者单位： 中国科学院合肥物质科学研究院

项目金额： 68万元

中文摘要： 强磁场是现代前沿科学研究重要极端条件之一。随着强磁场科学与技术的发展，强磁场对生物有机体的作用及相关机制研究已成为人们所关注的重要科学问题之一。细胞凋亡是在所有多细胞生物中起关键作用的基本生命过程，具有重要的生物学意义和临床意义。本项目拟依托中国科学院强磁场科学中心大科学装置，利用秀丽隐杆线虫及其基因缺陷型品系，系统研究稳态强磁场下细胞凋亡与磁场强度、暴露时间及暴露方式之间的量变规律，解析稳态强磁场下细胞凋亡的基因调控机制，揭示稳态强磁场下细胞凋亡程序启动的关键信号分子及信号传导通路，为阐明生物有机体对稳态强磁场的响应及生物安全边界标准的建立提供新的实验基础，并为稳态强磁场在生物医学领域的应用提供重要依据。

中文关键词： 稳态强磁场；秀丽隐杆线虫；细胞凋亡；发育异常；信号通路

英文摘要： The strong static magnetic field (SMF) is one of the important extreme conditions of the frontiers in modern science. With the development of the science and technology of SMF, the interaction of SMF and the biological organism and the involved mechanism(s) have caused great concerns and become one of the substantially scientific issues. Apoptosis is the process of programmed cell death (PCD) that may occur in multicellular organisms. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in an extensive variety of diseases such as cancer. Based on the facilities located in the High Magnetic Field Laboratory of the Chinese Academy of Sciences, the present project was focused on the apoptotic process under SMF in caenorhabditis elegans to clarify the relationship between the apotosis and the exposure time and the magnetic field intensity, the mechanism(s) of apotosis induced by SMF which involved the key regulation genes and the signal pathway. Our data will provide novel evidence on the response of the biological organisms to SMF and the exposure standard of SMF, which will be helpful in the application of SMF.

英文关键词： strong static magnetic fields；c. elegans；apoptosis；develpment abnormal；signal pathway