初级组装体的模块化组装、功能集成与仿生应用

项目名称： 初级组装体的模块化组装、功能集成与仿生应用

项目编号： No.91527304

项目类型： 重大研究计划

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 周永丰

作者单位： 上海交通大学

项目金额： 295万元

中文摘要： 当前分子自组装研究已经取得了极大进展，但和自然界高度复杂和智能的自组装过程相比，依然存在组装体结构过于简单，组装体功能单一的问题。为此，本项目拟以初级组装体为组装基元，通过它们之间的可控分子识别和协同组装，形成多个组装结构集成的组装体系，在提高组装体的尺寸和结构复杂性的同时，积极拓展其仿生功能。研究内容包括：1）囊泡的体系化自组装。通过功能分子在超支化聚合物囊泡膜内或膜上自组装，结合DNA折纸技术，构筑具有类细胞结构的复杂囊泡体系；2）囊泡的各向异性自组装。在可控制备补丁囊泡（patch vesicles）的基础上，通过和其他组装体或纳米粒子之间的识别和组装，构筑各向异性的囊泡功能体系；3）囊泡组装体系的仿生应用。以所制备的囊泡体系为模型，模仿细胞间的通讯，自然界的光合作用和细菌的定向运动等过程。希望通过本项目研究，为分子自组装研究向体系化和智能化方向发展提供新的思路和方法。

中文关键词： 可控自组装；刺激响应性；聚集态结构；功能化

英文摘要： Although great progress has been made, the research of supramolecular self-assembly of synthetic molecules still pales in comparison to the self-assembly in nature in both the structures and functionalities. In the project, we hope to perform the further self-assembly of preformed primary self-assemblies into complex supramolecular systems and studied the biomimetic applications of them. This project includes three parts. In the first part, the self-assembly of functional molecules inside or on the vesicle membranes together with DNA origami will be studied, in order to obtained supramolecular structures that mimic real cells. Such a process has been defined as systematized self-assembly. In the second part, the patch vesicles will be prepared through the controlled lateral phase separation of functional polymers on the vesicle membranes, which are used to bind other supramolecular structures or nanoparticles to form anisotropic functional self-assembly systems. Such a process has been defined as anisotropic self-assembly of vesicles. In the third part, the obtained complex vesicles have been used as the model systems to mimick the cellular processes like cell communications, light harvesting and bacterial motion. We believe the present project will give a new light on the development of self-assembly into a more smart and complex level.

英文关键词： Controlled self-assembly;stimuli responsive;aggregationg;functionalization