基于9.4T磁共振成像技术的婴幼猕猴脑运动中枢与运动行为发育关联性研究

项目名称： 基于9.4T磁共振成像技术的婴幼猕猴脑运动中枢与运动行为发育关联性研究

项目编号： No.31501866

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 生物科学

项目作者： 朱勇

作者单位： 中国科学院合肥物质科学研究院

项目金额： 20万元

中文摘要： 婴幼儿脑运动中枢发育与运动行为发育是目前脑科学和行为学关注的重要科学问题，其中对于二者在发育过程中呈因果关系还是线性关系仍存在争议。作为人类脑科学研究的重要模式动物—非人灵长类动物，是探索该问题的理想实验对象。本研究以实验猕猴(Macaca mulatta)为对象，运用目前国内最先进的9.4T超高场动物磁共振成像系统，研究0-6月龄婴幼猴脑运动中枢在不同发育阶段的结构变化特征，同时结合灵长类动物行为学取样方法，分类定义婴幼猴运动行为发育指标，研究个体运动行为发育特征并进行发育评价，阐明运动中枢发育结构变化与运动行为发育变化之间的量化关系，进而探讨婴幼猴脑运动中枢发育与运动行为发育的关联机制。通过本研究预期建立一套评估婴幼猴个体运动行为发育的测量方法，为非人灵长类动物脑发育与行为发育的关联模型提供基础数据和科学依据；同时，对理解人类婴幼儿运动神经与行为发育机制也具有极其重要的科学参考价值。

中文关键词： 磁共振成像；婴幼猴；脑运动中枢发育；运动行为发育；关联性

英文摘要： Understanding how the brain motorium works and the motor behavior development is one of the greatest challenges facing human brain science. In particular, for both the development process is causality or linear relationships is still controversial. Nonhuman primate is the most suitable experimental animal to study human brain and behavior development because of its close phylogenetic relationship with humans. But few study on infant nonhuman primate about brain and behavior development. This research focus on the infant (0-6 months age) rhesus macaque (Macaca mulatta) to study the brain motorium development using a 9.4T high field magnetic resonance imaging (MRI), and to study motor behavior development using behavior sampling methods. Our goals are to clarify the quantitative correlation between brain motorium and motor behavior development in infant rhesus macaque, and also to establish a set of assessment method to assess infant macaque motor behavior development. The results of this project will provide critical information for future study on brain and behavior develop mechanism in nonhuman primate. Meanwhile, the restlts of this study have potential value to understanding brain motorium and motor behavior development mechanism in human society.

英文关键词： magnetic resonance imaging;infant rhesus macaque;brain motorium development;motor behavior development;correlation