聚N-异丙基丙烯酰胺/壳聚糖包覆Fe3O4纳米晶簇核/壳结构的制备及抗菌性应用

项目名称： 聚N-异丙基丙烯酰胺/壳聚糖包覆Fe3O4纳米晶簇核/壳结构的制备及抗菌性应用

项目编号： No.21201151

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 无机化学

项目作者： 乔儒

作者单位： 浙江师范大学

项目金额： 25万元

中文摘要： 为解决Fe3O4纳米晶及晶簇制备中出现的粒度分布不易控制及生长粒径过大导致顺磁-铁磁相变的问题，该申请提出采用高温水解法，并通过优化反应参数以制备具有良好分散性、粒度分布较窄且磁性能优越的Fe3O4纳米晶簇。后续工作以此为核材制备可磁回收重复利用的核/壳结构复合抗菌剂。针对申请人在研的SiO2包覆磁性粒子作为抗菌剂载体应用中出现的金属粒子在SiO2表面脱附、团聚造成抗菌性降低的问题，申请提出将壳层包覆物改为具有开放网络结构的聚N-异丙基丙烯酰胺（p-NIPAM）以固载抗菌剂粒子来解决该问题。为改善温度及pH值变化对p-NIPAM的影响并提高金属抗菌剂的抗菌性能，该课题设计将具有广谱抗菌性的壳聚糖（CS）与p-NIPAM联接制备半互穿壳层结构。以上述所得Fe3O4@p-NIPAM/CS为载体，在壳层网络结构中导入纳米银，制备磁性复合抗菌剂，通过其协同作用和优势互补，提高抑菌率并延长抗菌周期。

中文关键词： 四氧化三铁；聚N-异丙基丙烯酰胺；核壳结构；抗菌实验；光催化抗菌

英文摘要： In the preparation of magnetite nanocrystals and crystal clusters, the particle size distribution is not easily controlled which often results in paramagnetic-ferromagnetic phase transition and prevents its wide spread usage in some fields. So we introduce the high-temperature hydrolysis method, by optimizing the influencing factors, to produce the magnetite nanocrystal clusters possessing the characters of perfect dispersity, narrow size distribution, and excellent magnetic property which will be used as core materials in the following process of preparation of magnetically recoverable antibacterial supports. In our ZJNSF project about preparation of magnetic nanoparticles@SiO2 core-shell structures as antibacterial supports, with the content increase of metal nanoparticles precipitated onto SiO2 surface, the phenomena of the particle desorption and aggregation were occurred which affected the antibacterial performance of the nanocomposites. Thus the second purpose of the application is using thermo-sensitive poly(N-isopropylacrylamide) (p-NIPAM) to replace silica as shell materials to produce the composite core-shell structures. It can be expected that the network structure of p-NIPAM will firmly lay hold of the embedded particles to avoid their desorption and aggregation. To improve the effect of temperature

英文关键词： Magnetite nanocrystal clusters；poly(N-isopropylacrylamide)；core-shell structure；antibacterial test；photocatalytic antibacterial property