The identification of latent mediator variables is typically conducted using standard structural equation models (SEMs). When SEM is applied to mediation analysis with a causal interpretation, valid inference relies on the strong assumption of no unmeasured confounding, that is, all relevant covariates must be included in the analysis. This assumption is often violated in empirical applications, leading to biased estimates of direct and indirect effects. We address this limitation by weakening the causal assumptions and proposing a procedure that combines g-estimation with a two-stage method of moments to incorporate latent variables, thereby enabling more robust mediation analysis in settings common to the social sciences. We establish consistency and asymptotic normality of the resulting estimator. Simulation studies demonstrate that the estimator is unbiased across a wide range of settings, robust to violations of its underlying no-effect-modifier assumption, and achieves reasonable power to detect medium to large effects for sample sizes above 500, with power increasing as the strength of treatment-covariate interactions grows.
翻译:潜在中介变量的识别通常采用标准结构方程模型(SEM)进行。当将SEM应用于具有因果解释的中介分析时,有效的推断依赖于无未测量混杂的强假设,即所有相关协变量都必须纳入分析。这一假设在实证应用中常被违背,导致直接效应和间接效应的估计产生偏差。我们通过弱化因果假设来解决这一局限,提出了一种将g估计与包含潜在变量的两阶段矩估计法相结合的程序,从而在社会科学常见情境中实现更稳健的中介分析。我们证明了所得估计量的一致性和渐近正态性。模拟研究表明,该估计量在多种设定下均无偏,对其基础无效应修饰假设的违背具有稳健性,且在样本量大于500时对中等到大效应具备合理的检测功效,且功效随处理-协变量交互作用强度的增强而提升。