Image denoising is a critical component in a camera's Image Signal Processing (ISP) pipeline. There are two typical ways to inject a denoiser into the ISP pipeline: applying a denoiser directly to captured raw frames (raw domain) or to the ISP's output sRGB images (sRGB domain). However, both approaches have their limitations. Residual noise from raw-domain denoising can be amplified by the subsequent ISP processing, and the sRGB domain struggles to handle spatially varying noise since it only sees noise distorted by the ISP. Consequently, most raw or sRGB domain denoising works only for specific noise distributions and ISP configurations. To address these challenges, we propose DualDn, a novel learning-based dual-domain denoising. Unlike previous single-domain denoising, DualDn consists of two denoising networks: one in the raw domain and one in the sRGB domain. The raw domain denoising adapts to sensor-specific noise as well as spatially varying noise levels, while the sRGB domain denoising adapts to ISP variations and removes residual noise amplified by the ISP. Both denoising networks are connected with a differentiable ISP, which is trained end-to-end and discarded during the inference stage. With this design, DualDn achieves greater generalizability compared to most learning-based denoising methods, as it can adapt to different unseen noises, ISP parameters, and even novel ISP pipelines. Experiments show that DualDn achieves state-of-the-art performance and can adapt to different denoising architectures. Moreover, DualDn can be used as a plug-and-play denoising module with real cameras without retraining, and still demonstrate better performance than commercial on-camera denoising. The project website is available at: https://openimaginglab.github.io/DualDn/
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