In this paper, we study the design and analysis of experiments conducted on a set of units over multiple time periods where the starting time of the treatment may vary by unit. The design problem involves selecting an initial treatment time for each unit in order to most precisely estimate both the instantaneous and cumulative effects of the treatment. We first consider non-adaptive experiments, where all treatment assignment decisions are made prior to the start of the experiment. For this case, we show that the optimization problem is generally NP-hard and we propose a near-optimal solution. Under this solution the fraction entering treatment each period is initially low, then high, and finally low again. Next, we study an adaptive experimental design problem, where both the decision to continue the experiment and treatment assignment decisions are updated after each period's data is collected. For the adaptive case we propose a new algorithm, the Precision-Guided Adaptive Experiment (PGAE) algorithm, that addresses the challenges at both the design stage and at the stage of estimating treatment effects, ensuring valid post-experiment inference accounting for the adaptive nature of the design. Using realistic settings, we demonstrate that our proposed solutions can reduce the opportunity cost of the experiments by over 50\%, compared to static design benchmarks.
翻译:在本文中,我们研究在多个时期对一组单元进行的实验的设计和分析,这些实验的起始时间因单位而异。设计问题涉及为每个单元选择初步治疗时间,以便最精确地估计治疗的瞬间和累积效应。我们首先考虑非适应性实验,所有治疗分配决定都是在实验开始前作出的。我们在此案中表明,优化问题一般是NP硬性的,我们建议一种近于最佳的解决办法。在这个解决办法下,每个阶段进入治疗的分数最初较低,然后是高的,最后是低的。接下来,我们研究适应性实验设计问题,即每个单元选择初步治疗时间,以便最精确地估计治疗的瞬间和累积效应。我们首先考虑非适应性试验试验,在收集每个时期的数据后,对治疗分配决定进行更新。对于适应性案例,我们提出一种新的算法,即Precision-Guid适应性实验(PGAE)算法,处理设计阶段和估计治疗效果阶段的挑战,确保对设计适应性进行有效的后推算。我们提出的解决办法可以通过现实的设置来比较50个基准,我们提出的解决办法可以降低对设计进行试验的机会成本。