A fourth-order exponential time differencing (ETD) Runge-Kutta scheme with dimensional splitting is developed to solve multidimensional non-linear systems of reaction-diffusion equations (RDE). By approximating the matrix exponential in the scheme with the A-acceptable Pad\'e (2,2) rational function, the resulting scheme (ETDRK4P22-IF) is verified empirically to be fourth-order accurate for several RDE. The scheme is shown to be more efficient than competing fourth-order ETD and IMEX schemes, achieving up to 20 times speed in CPU time. Inclusion of up to three pre-smoothing steps of a lower order L-stable scheme facilitates efficient damping of spurious oscillations arising from problems with non-smooth initial/boundary conditions.
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