基于系统评价和临床对照框架的腹腔镜结直肠癌根治术理论及应用研究

项目名称： 基于系统评价和临床对照框架的腹腔镜结直肠癌根治术理论及应用研究

项目编号： No.71203125

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 宏观管理与政策

项目作者： 李雪梅

作者单位： 山东大学

项目金额： 19万元

中文摘要： 腹腔镜结直肠癌根治术较传统手术具有微创等优势，其作为一种新技术日益被医生和患者所接受，并广泛应用。但是腹腔镜结直肠癌根治术的安全性和远期疗效始终是该专业领域备受争议的热点，其与国情相关的卫生经济学价值和社会价值探讨也逐渐纳入人们的视野。目前，国内外尚缺乏针对该技术证据等级较高的系统评价，尤其是全方位的系统评价研究。同时，我国缺乏针对该技术临床指标和卫生经济学等指标的高质量研究- - 多中心前瞻性随机对照研究，以确实证明和探讨腹腔镜结直肠癌根治术是否适用于中国人，适合于我国国情。因此，本研究拟对腹腔镜结直肠癌根治术进行系统的技术评估，形成高质量的系统评价，同时展开多中心前瞻性随机对照研究，将理论研究结论和临床对照研究结果有机结合，多方面系统评价腹腔镜结直肠癌根治术，并全面评估该技术在我国应用的疗效等具体指标，从而为该技术的临床应用提供指导性参考，为相关卫生决策提供科学依据。

中文关键词： 结直肠癌；腹腔镜手术；开腹手术；卫生技术评估；临床试验

英文摘要： Laparoscopic resection of colorectal cancer as an alternative to traditional open operation ，has been accepted by an increasing number of surgeons and patients. However, there is a dispute about safety and long-term efficacy after laparoscopic resection for colorectal cancer in the professional field and the value of health economics and sociology has been involved. Until now the high-grade system assessment for laparoscopic resection of colorectal cancer has been lacking, especially involved in the omnibearing indexes. In the same time, adequately randomized controlled, multiple center clinical trials are still imperative for discussing the relative indexes of clinical, health economic and sociology in China and as the foundation of verifying whether laparoscopic surgery is suitable to Chinese and China. Therefore in the study the high-grade system assessment and randomized controlled, multiple center clinical trials are implemented. According to the results of academic research and clinical trails we will comprehensively evaluate laparoscopic resection of colorectal cancer overall and separately evaluate relative indexes including efficacy, health economics and sociology and so on. The conclusion of the study would provide instructional reference for clinical application and scientific basis for health strateg

英文关键词： colorectal cancer；laparoscopic surgery；open surgery；health technology assessment；clinical trails