飞秒瞬态光谱测量和相干控制研究新型光敏剂咔咯能量转移和电荷转移过程

项目名称： 飞秒瞬态光谱测量和相干控制研究新型光敏剂咔咯能量转移和电荷转移过程

项目编号： No.61475196

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 张蕾

作者单位： 中山大学

项目金额： 90万元

中文摘要： 近年来我国癌症发病率不断上升，光动力学疗法(Photodynamic Therapy,PDT)作为一种新型治疗方法备受关注。由于咔咯及其衍生物优良的靶组织选择性，体内代谢快、PDT活性高，使其有望成为新一代具有分子识别能力的智能型光敏剂，因此合成和研究新型光敏剂成为非常重要的研究方向。 本项目拟用超快光谱技术研究新型光敏剂咔咯（corrole）的光物理和光化学特性，进行用于光动力治疗药物的筛选。研究咔咯超快振动弛豫、系间窜越几率和单线态氧几率与周边取代基和中心金属的关系；以及水溶性镓咔咯与DNA复合物之间的超快电荷转移过程，用量子相干调控控制咔咯系间窜越和单线态氧产率，以及水溶性镓咔咯与DNA复合物之间的超快电荷转移过程。

中文关键词： 超快光谱；飞秒激光；超快现象

英文摘要： The incidence of cancer has increased in recent years. Photodynamic therapy (PDT) is a treatment that uses a drug, called a photosensitizer and a particular type of light. When photosensitizers are exposed to a specific wavelength of light, they produce a form of oxygen that kills nearby cells. Corrole and its derivatives were found to function both for tumor detection and intervention with safety and targeting advantages over standard chemotherapeutic agents. Therefore it is very important to investigate its photophysical and photochemical characters and select candidates for anticarcinogens. We will investigate the influence of periphecal groups and center mental on the ultrafast vibrational relaxation process，quantum yield of intersystem crossing and singlet oxygen. The electron transfer process between the water-soluble corroles and DNA will also be studied. In addition, we will use a femtosecond laser source with adaptive pulse shaping together with a molecular feedback in a learning loop to search for and synthesize such 'smart' laser pulses. Our control objective is to enhance the triplet yield of a model photosensitizer water-soluble corrole, which then leads to enhancement of the overall PDT process. We will also use the same method to control the process of electron transfer between water-soluble corrole and DNA.

英文关键词： ultrafast spectroscopy;femtosecond laser