抗癫痫类药物在表层水环境中的间接光解过程机理研究

项目名称： 抗癫痫类药物在表层水环境中的间接光解过程机理研究

项目编号： No.11305099

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 刘宁

作者单位： 上海理工大学

项目金额： 28万元

中文摘要： 药物类污染物作为新兴污染物已引起广大环境工作者的广泛关注，其在水环境中的迁移转化已成为目前的研究热点。本项目以环境中广泛存在的抗癫痫类药物（AEDs）为研究对象，选择多种人工和天然光敏化剂，研究AEDs在模拟太阳光作用下的间接光解特性及动力学，并采用分子探针技术测定羟基自由基、单线态氧和三线态光敏化剂等活性粒子的稳态浓度。采用脉冲辐解和激光光解的时间分辨方法对AEDs的瞬态产物进行分析，确定其种类、相应的物理化学参数及瞬态反应动力学。研究不同水质参数对AEDs间接光解的影响，建立各水质参数与AEDs间接光解之间的关联模型。运用发光菌等生物测试手段测定AEDs的光解产物的毒性情况。同时结合光解过程中的稳态产物分析情况，阐明AEDs的间接光解机理。从而有效的预测这类污染物在地表水环境中的间接光化学过程变化，为环保部门预测该类新兴污染物的环境归趋和生态风险评估提供科学依据。

中文关键词： 抗癫痫药物；光降解；反应动力学；降解机理；产物毒性

英文摘要： Pharmaceuticals as one kind of the emerging contaminants have aroused worldwide attention. At present, their removal and transformation in water environment have become one of the research hotspots in the world. The indirect photolysis of antiepileptic drugs (AEDs) was investigated by the combination of transient and stable technologies. In the project, many kinds of photosensitizers including the manmade and natural were used to study the indirect photolysis mechanism of AEDs. The indirect photolysis characteristic and kinetics of AEDs by imitation sunlight were studied. The steady state concentrations of hydroxyl radical, singlet oxygen and triplet photosensitizer were determined by molecule probe technique. The property and kinetics characteristic of transient products waere studied by laser flash photolysis and pulse radiolysis. The effect of different water quality parameters on AEDs indirect photolysis and the relationship between water quality parameters and AEDs indirect photolysis were also investigated in this project. In addition, the photobacteria were used to measure the toxicity of the photolysis products. Meanwhile, to combine the steady state products analysis, the indirect photolysis mechanism was clarified in the project. The aim of the project was to predict the change of indirect photochem

英文关键词： Antiepileptic drugs；Photolysis；Reaction kinetics；Degradation mechanism；Toxicity