基于“阴病治阳”理论探讨电针背俞穴对PMOP患者筛选后骨代谢差异蛋白作用机制的临床研究

项目名称： 基于“阴病治阳”理论探讨电针背俞穴对PMOP患者筛选后骨代谢差异蛋白作用机制的临床研究

项目编号： No.81674054

项目类型： 面上项目

立项/批准年度： 2017

项目学科： 医药、卫生

项目作者： 郑雪峰

作者单位： 福建中医药大学

项目金额： 25万元

中文摘要： 研究表明，PMOP患者一些特异性骨代谢指标的改变较骨密度早而且明显，通过筛选出不同骨量绝经后妇女血中特异性骨代谢差异蛋白，有助于进一步明确电针对PMOP的早期疗效及诊治方案调整，从而更客观地阐明电针防治PMOP的蛋白组学效应，为PMOP寻求安全有效的中医特色外治方法，有着潜在的临床应用和推广前景。因此，本研究基于《素问•阴阳应象大论》中“阴病治阳”的中医理论，即五脏有病多刺背俞穴的治则，拟采用具有高通量、高灵敏度的悬液芯片技术筛选出不同骨量绝经后妇女血中特异性骨代谢差异蛋白，在课题组前期以补肾健脾为治法的基础上，观察电针肾俞、脾俞对PMOP患者主要骨代谢差异蛋白的影响，揭示背俞穴防治PMOP的蛋白组学效应，为寻求早期、便捷以及安全、有效的中医诊疗PMOP方法提供思路和依据。

中文关键词： 背俞穴；绝经后骨质疏松症；骨代谢；差异蛋白；临床研究

英文摘要： Researches show that the change of some specific bone metabolic indices in PMOP patients is more early and obvious than BMD. It will help further clarify the effect of PMOP and adjustment of the treatment plan by screening out specific bone metabolic protein of different bone mass in postmenopausal women. And it is more objective to clarify proteomics effect of the prevention and treatment of PMOP by the therapy of electroacupuncture, help to develop a safe and effective external treatment therapy of Chinese medicine that has potential clinical application and prospects. Therefore, based on the “Treating Yang for Yin Disease” in Shu Wen Yin Yang Ying Xiang Methodology of traditional Chinese medicine theory, namely the therapeutic principle of that it always acupuncture back-shu points when five zang-organs is sick, this study intends to screen out specific bone metabolic protein of different bone mass in postmenopausal women by suspension chip technology, observe the effect of Shenshu point and Pishu point by the therapy of electroacupuncture on specific bone metabolic protein of different bone mass and reveal proteomics effect of back-shu points on PMOP. It will provide a basis and thinking method for developing a safe and effective external treatment therapy of Chinese medicine.

英文关键词： Bei-shu point;Postmenopausal osteoporosis;Bone metabolism;Differential protein;Clinical research