基于功能化纳米纤维的优越固相萃取介质两元结构吸附机理及其应用研究

项目名称： 基于功能化纳米纤维的优越固相萃取介质两元结构吸附机理及其应用研究

项目编号： No.81473019

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 许茜

作者单位： 东南大学

项目金额： 85万元

中文摘要： 纳米纤维的特殊形态结构使其极具优越固相萃取（SPE）介质的潜质，基于纳米纤维的SPE因此成为新兴的样品预处理技术，明确纳米纤维高效吸附目标物的机理是新技术发展的关键科学问题。申请人的预研结果表明纳米纤维的两元结构（分子结构和纳米形态结构）与目标物吸附效能之间存在结构-效应关系，提示以构效关系为核心进行吸附机理研究的合理性和可行性。但目前分子结构方面的研究缺乏代表性和系统性，纳米形态结构与对目标物吸附效能的关系研究还未见报道。本项目将同时系统研究功能化纳米纤维的代表性分子结构及典型纳米形态结构与目标物的吸附选择性和吸附效率等吸附效能之间的关系，探究吸附机理，发现吸附规律，并验证其指导食品安全分析、环境污染监测等实际应用的可靠性。预期在基于纳米纤维SPE技术研究领域占领先机、取得突破。

中文关键词： 纳米纤维；样品预处理；吸附机理；有机污染物；环境激素

英文摘要： For the special characteristics of nanostructure, now nanofibers have been considered as a potential kind of sorbent material for SPE. Nanofiber-based solid-phase extraction also becomes a popular research point of sample pretreatment technique.The key to develop the new technology is to clear how the target compounds can be effectively adsorbed by nanofibers. Our previous researches show that there is a dual structure-activity relationship between target adsorption efficiency and the two structures of nanofibers, including molecular structure and nanometer morphological structure.So it is reasonable and feasible to choose the structure activity relationship as the study point of adsorption mechanism. However, at present,the aspect of molecular structure is short of representative and systemic research. Among the published researches, there is few about the nanostructure influence on the adsorption efficiency.The project will systematically focus on the relationship between the functionalized nanofibers molecular structure and typical nanostructure and adsorption efficiency, such as adsorption selectivity and efficiency of the target. The research will explore the adsorption mechanism and demonstrate the law of adsorption ,then verify the feasibility of appplictions of the adsorption mechanism and law in food safety analysis and environment pollution monitoring, with an expect of taking advanced status and making breakthrough in the field of nanofibers based solid-phase extraction technique research.

英文关键词： nanofibers;sample pretreatment;adsorption mechanism;organic pollutant;environmental endocrine