活体监测人体数字模型动态虚拟校准方法研究

项目名称： 活体监测人体数字模型动态虚拟校准方法研究

项目编号： No.11275174

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 刘立业

作者单位： 中国辐射防护研究院

项目金额： 80万元

中文摘要： 效率校准是内照射活体监测中一项关键技术，也是影响人体内污染活体测量准确性的一个重要因素。如何实现效率校准环节的数值模拟，是从技术层面上提高内照射监测一致性、准确性以及核事故应急监测数据处理速度的基础性问题。本项目拟在已有人体数字模型和内照射生物动力学研究的基础上，从系列化中国人体数字模型库建立、探测器自动虚拟表征、快速虚拟校准方法、生物动力学模式与人体数字模型融合、实验验证等几个方面着手开展研究，建立内照射活体监测用人体数字模型动态虚拟校准方法，并完成虚拟校准软件的开发验证工作。从而实现效率校准过程的数值模拟，突破阻碍一体化内照射应用软件开发的技术瓶颈。此外，本项目还将在研究中，提出较为先进的模型调整方法、常用探测器的自动表征方法，并建立具有生物动力学代谢过程的动态人体数字模型，这也是在辐射防护领域将人体数字模型从"物理人"向"生理人"发展的有益尝试，未来可能具有广泛的应用价值和研究意义。

中文关键词： 内照射；效率校准；人体数字模型；蒙特卡罗方法；生物动力学

英文摘要： Efficiency calibration technique plays an important role for in-vivo internal contamination monitoring of human body, and it also has a great influence on the measurement accuracy. Numerical simulation of the efficiency calibration process is a basic unsolved problem for improving the consistence and accuracy of in-vivo monitoring, and it is also one of the key elements to enhance the data interpretation process for accident monitoring under the nuclear accident circumstance. This project is intended to establish a new technology, called biokinetic virtual efficiency calibration method, based on human voxel phantoms and ICRP-biokinetic models for in-vivo monitoring. It consists of several research elements as follows: the construction of a database of Chinese human voxel models, detector's automatic modeling, fast efficiency calculation technique, the merging of human voxel model with ICRP-biokinetic models, experimental validation and the software development. The output of this project would have a wider significance for in-vivo monitoring, since it technically solves the basic obstacle for developing the integrated multi-functional internal dose assessment software, which is a longtime-desired objective in radiation protection field. Meanwhile, several important techniques also would be developed through this

英文关键词： Internal Exposure；Efficiency Calibration；Human Voxel Phantom；Monte Carlo Method；Biokinetics