项目名称: 高血压认知损伤的APOE基因遗传风险与脑神经机制研究
项目编号: No.31500922
项目类型: 青年科学基金项目
立项/批准年度: 2016
项目学科: 神经、认识与心理学
项目作者: 李馨
作者单位: 北京师范大学
项目金额: 20万元
中文摘要: 目前认为高血压是痴呆的高危因素,其引起的认知损伤及其神经机制已成为神经科学家关注的重点。因此,阐明其脑损伤特征及其生物学机制对于高血压的认知保持和痴呆的早期防控都具有重要意义。大脑整体性的信息交流与整合是保持认知能力完成的神经基础。既往研究分别对高血压和APOE4基因造成的脑局部损伤进行了报道,而对于大脑整体性研究则报道较少;二者的交互作用分析显示APOE4基因加重高血压患者的认知损伤,但是目前对此的神经机制研究一直是空白。本研究将利用基于图论构建的脑白质网络分析方法,重点考察APOE基因多态性对于高血压认知损伤及其脑结构网络的调节作用,从全脑整体性视角揭示APOE基因影响高血压致脑损伤的途径,为遗传因素在高血压的认知损伤及脑神经变化中的影响作用提供实验证据。
中文关键词: 高血压;基因;脑网络;认知障碍
英文摘要: Hypertension is an important disease risk factor of Alzheimer Disease. Neuroscientists pay more attention on the neuro-mechanism of hypertension-induced cognitive impairments. Exploring the cognitive impairments and biological mechanism is very important for cognitive protection in hypertensive patients. The panoply of cognitive functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Previous studies have reported that hypertension and APOE gene induced regional brain injuries, but there is little study about the whole brain. APOE genotype moderates the association between hypertension and cognitive decline, but the neuromechism of the moderation is less.Present research would apply graph-based brain network analysis, try to discover how APOE gene polymorphism regulate the cognitive impairment and brain alteration led by hypertension, and demonstrate the pathological changes from a whole-brain level, and provide experimental evidence for the regulating role of the gene effect plays in the hypertension-induced cognitive declination and brain damage.
英文关键词: hypertension;APOE gene;brain networks;cognitive impairment