应用多模态fMRI探讨交泰丸治疗抑郁症患者的脑机制研究

项目名称： 应用多模态fMRI探讨交泰丸治疗抑郁症患者的脑机制研究

项目编号： No.81503390

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 周志焕

作者单位： 天津中医药大学

项目金额： 18万元

中文摘要： 古方交泰丸由黄连和肉桂两味药组成，是临床治疗失眠及抑郁症的常用方，失眠不但是抑郁症最常见症状，又是抑郁症加重的诱发因素。抑郁症的发生与神经递质功能紊乱密切相关，神经递质紊乱在睡眠障碍中也发挥着重要作用。课题组前期动物实验研究表明交泰丸在小鼠悬尾和强迫游泳实验两种动物行为绝望模型上具有抗抑郁作用，并可通过调节海马组织和皮质中NE和5-HT含量而发挥抗抑郁作用，但交泰丸抗抑郁的临床作用机制尚未见文献报道。本研究以轻中度抑郁症患者为研究对象，以HAMD量表为疗效评价标准，联合应用多模态fMRI技术（包括BOLD-fMRI、DTI、MRS），并结合血浆神经递质及威斯康星卡片分类心理测试，分析交泰丸配方颗粒剂对抑郁症患者神经递质、脑白质微观结构以及静息状态下脑功能活动的影响，观察交泰丸是否通过调节神经递质来改善脑结构及功能，从而对抑郁症患者发挥治疗作用，从影像学水平探讨交泰丸治疗抑郁症患者的脑机制。

中文关键词： fMRI；交泰丸；抑郁症；脑机制

英文摘要： Jiaotai pill of ancient prescription is composed of two herbs of Huanglian and Rougui, is commonly used in the clinical treatment of insomnia and depression, insomnia is the most common symptoms of depression, also is a predisposing factor of depression. Depression is closely related to the neurotransmitter disorders, neurotransmitter disorders also play an important role in sleep disorders. Research group preliminary animal studies have shown that Jiaotai pill has antidepressant effect on the two kinds of animal behavior despair model of mouse tail suspension and forced swimming test, and has antidepressant effect by regulation NE and 5-HT content in hippocampus and cortex, but antidepressant mechanism of Jiaotai pill has not been reported in clinical literature. In this study, we select light and moderate depression patients as the research object, take HAMD scale for curative effect evaluation standard, combined application of functional magnetic resonance imaging technology(including BOLD-fMRI, DTI, MRS), and combined with plasma neurotransmitter and Wisconsin card sorting test, analysis effect of Jiaotai pill formula granules on neurotransmitters, alba microstructure and brain activity on resting state in patients with depression, observe whether Jiaotai pill is by regulating neurotransmitter to improve brain structure and function, and thus play therapeutic effect in patients with depression, from imaging level to explore brain mechanisms of Jiaotai pill on patients with depression.

英文关键词： fMRI;Jiaotai pill;depression;brain mechanism